The contribution refers to Miloš O. Bondy and intelligence from Protektorat Bohemia and Moravia

Agus, Michael S. D.

Alhazzani, Waleed

Argent, Andrew C.

BRIERLEY, Joe

Carcillo, Joseph

Carrol, Enitan D.

Carroll, Christopher L.

Cheifetz, Ira M.

Choong, Karen

Cies, Jeffry J.

Cruz, Andrea T.

De Luca, Daniele

De Oliveira, Claudio Flauzino

Deep, Akash

Faust, Saul N.

Flori, Heidi R.

Hall, Mark W.

Inwald, David P.

Ishimine, Paul

Javouhey, Etienne

Joosten, Koen F. M.

Joshi, Poonam

Karam, Oliver

Kissoon, Niranjan

KNEYBER, Martin C. J.

Lemson, Joris

Maclaren, Graeme

Mehta, Nilesh M.

Møller, Morten Hylander

Nadel, Simon

Newth, Christopher J. L.

Nguyen, Trung C.

Nishisaki, Akira

Nunnally, Mark E.

Parker, Margaret M.

Paul, Raina M.

Peters, Mark J.

Randolph, Adrienne G.

Ranjit, Suchitra

Romer, Lewis H.

SCHLAPBACH, Luregn J.

Scott, Halden F.

TASKER, Robert C.

Tissieres, Pierre

Tume, Lyvonne N.

Verger, Judy T.

Weiss, Scott L.

Williams, Eric A.

Wolf, Joshua

Wong, Hector R.

Zimmerman, Jerry J.

Intensive Care Medicine

Weiss, S.L.

Peters, M.J.

Alhazzani, W.

Agus, M.S.D.

Flori, H.R.

Inwald, D.P.

Nadel, S.

Schlapbach, L.J.

Tasker, R.C.

Argent, A.C.

Brierley, J.

Carcillo, J.

Carrol, E.D.

Carroll, C.L.

Cheifetz, I.M.

Choong, K.

Cies, J.J.

Cruz, A.T.

Luca, D. De

Deep, A.

Faust, S.N.

Oliveira, C.F. De

Hall, M.W.

Ishimine, P.

Javouhey, E.

Joosten, K.F.

Joshi, P.

Karam, O.

Kneyber, M.C.J.

Lemson, J.

MacLaren, G.

Mehta, N.M.

Møller, M.H.

Newth, C.J.

Nguyen, T.C.

Nishisaki, A.

Nunnally, M.E.

Parker, M.M.

Paul, R.M.

Randolph, A.G.

Ranjit, S.

Romer, L.H.

Scott, H.F.

Tume, L.N.

Verger, J.T.

Williams, E.A.

Wolf, J.

Wong, H.R.

Zimmerman, J.J.

Kissoon, N.

Tissieres, P.

NARCIS 

Executive Summary: Surviving Sepsis Campaign International Guidelines for the Management of Septic Shock and Sepsis-Associated Organ Dysfunction in Children

In 2001, the Surviving Sepsis Campaign (SSC) began to develop evidence-based guidelines and recommendations for the resuscitation and management of patients with sepsis. With the 2016 edition, the Society of Critical Care Medicine and European Society of Intensive Care Medicine recommended a separate task force be dedicated to guideline formulation for children. The objective of the “Surviving Sepsis Campaign International Guidelines for the Management of Septic Shock and Sepsis-associated Organ Dysfunction in Children” is to provide guidance for the care of infants, children, and adolescents with septic shock and other sepsis-associated organ dysfunction. Recommendations are intended to guide “best practice” rather than to establish a treatment algorithm or to define standard of care and cannot replace the clinician's decision-making capability when presented with a patient's unique set of clinical variables.</p

Agus, Michael S.D.

Schlapbach, Luregn J.

Tasker, Robert C.

Brierley, Joe

de Luca, Daniele

de Oliveira, Claudio Flauzino

Joosten, Koen F.M.

Kneyber, Martin C.J.

MacLaren, Graeme

Newth, Christopher J.L.

EUR Research Repository

English

Executive summary:Surviving sepsis campaign international guidelines for the management of septic shock and sepsis-associated organ dysfunction in children

OBJECTIVES: To develop evidence-based recommendations for clinicians caring for children (including infants, school-aged children, and adolescents) with septic shock and other sepsis-associated organ dysfunction. DESIGN: A panel of 49 international experts, representing 12 international organizations, as well as three methodologists and three public members was convened. Panel members assembled at key international meetings (for those panel members attending the conference), and a stand-alone meeting was held for all panel members in November 2018. A formal conflict-of-interest policy was developed at the onset of the process and enforced throughout. Teleconferences and electronic-based discussion among the chairs, co-chairs, methodologists, and group heads, as well as within subgroups, served as an integral part of the guideline development process. METHODS: The panel consisted of six subgroups: recognition and management of infection, hemodynamics and resuscitation, ventilation, endocrine and metabolic therapies, adjunctive therapies, and research priorities. We conducted a systematic review for each Population, Intervention, Control, and Outcomes question to identify the best available evidence, statistically summarized the evidence, and then assessed the quality of evidence using the Grading of Recommendations Assessment, Development, and Evaluation approach. We used the evidence-to-decision framework to formulate recommendations as strong or weak, or as a best practice statement. In addition, "in our practice" statements were included when evidence was inconclusive to issue a recommendation, but the panel felt that some guidance based on practice patterns may be appropriate. RESULTS: The panel provided 77 statements on the management and resuscitation of children with septic shock and other sepsis-associated organ dysfunction. Overall, six were strong recommendations, 52 were weak recommendations, and nine were best-practice statements. For 13 questions, no recommendations could be made; but, for 10 of these, "in our practice" statements were provided. In addition, 49 research priorities were identified. CONCLUSIONS: A large cohort of international experts was able to achieve consensus regarding many recommendations for the best care of children with sepsis, acknowledging that most aspects of care had relatively low quality of evidence resulting in the frequent issuance of weak recommendations. Despite this challenge, these recommendations regarding the management of children with septic shock and other sepsis-associated organ dysfunction provide a foundation for consistent care to improve outcomes and inform future research

Agus, Michael S D

Kneyber, Martin C. J.

University of Queensland eSpace

Surviving Sepsis Campaign international guidelines for the management of septic shock and sepsis-associated organ dysfunction in children

Crossref

Objectives: To develop evidence-based recommendations for clinicians caring for children (including infants, school-aged children, and adolescents) with septic shock and other sepsis-associated organ dysfunction. Design: A panel of 49 international experts, representing 12 international organizations, as well as three methodologists and three public members was convened. Panel members assembled at key international meetings (for those panel members attending the conference), and a stand-alone meeting was held for all panel members in November 2018. A formal conflict-of-interest policy was developed at the onset of the process and enforced throughout. Teleconferences and electronic-based discussion among the chairs, co-chairs, methodologists, and group heads, as well as within subgroups, served as an integral part of the guideline development process. Methods: The panel consisted of six subgroups: recognition and management of infection, hemodynamics and resuscitation, ventilation, endocrine and metabolic therapies, adjunctive therapies, and research priorities. We conducted a systematic review for each Population, Intervention, Control, and Outcomes question to identify the best available evidence, statistically summarized the evidence, and then assessed the quality of evidence using the Grading of Recommendations Assessment, Development, and Evaluation approach. We used the evidence-to-decision framework to formulate recommendations as strong or weak, or as a best practice statement. In addition, “in our practice” statements were included when evidence was inconclusive to issue a recommendation, but the panel felt that some guidance based on practice patterns may be appropriate. Results: The panel provided 77 statements on the management and resuscitation of children with septic shock and other sepsis-associated organ dysfunction. Overall, six were strong recommendations, 49 were weak recommendations, and nine were best-practice statements. For 13 questions, no recommendations could be made; but, for 10 of these, “in our practice” statements were provided. In addition, 52 research priorities were identified. Conclusions: A large cohort of international experts was able to achieve consensus regarding many recommendations for the best care of children with sepsis, acknowledging that most aspects of care had relatively low quality of evidence resulting in the frequent issuance of weak recommendations. Despite this challenge, these recommendations regarding the management of children with septic shock and other sepsis-associated organ dysfunction provide a foundation for consistent care to improve outcomes and inform future research.</p

Edge Hill University Research Information Repository

Surviving sepsis campaign international guidelines for the management of septic shock and sepsis-associated organ dysfunction in children

OBJECTIVES: To develop evidence-based recommendations for clinicians caring for children (including infants, school-aged children, and adolescents) with septic shock and other sepsis-associated organ dysfunction.
DESIGN: A panel of 49 international experts, representing 12 international organizations, as well as three methodologists and three public members was convened. Panel members assembled at key international meetings (for those panel members attending the conference), and a stand-alone meeting was held for all panel members in November 2018. A formal conflict-of-interest policy was developed at the onset of the process and enforced throughout. Teleconferences and electronic-based discussion among the chairs, co-chairs, methodologists, and group heads, as well as within subgroups, served as an integral part of the guideline development process.
METHODS: The panel consisted of six subgroups: recognition and management of infection, hemodynamics and resuscitation, ventilation, endocrine and metabolic therapies, adjunctive therapies, and research priorities. We conducted a systematic review for each Population, Intervention, Control, and Outcomes question to identify the best available evidence, statistically summarized the evidence, and then assessed the quality of evidence using the Grading of Recommendations Assessment, Development, and Evaluation approach. We used the evidence-to-decision framework to formulate recommendations as strong or weak, or as a best practice statement. In addition,  in our practice  statements were included when evidence was inconclusive to issue a recommendation, but the panel felt that some guidance based on practice patterns may be appropriate.
RESULTS: The panel provided 77 statements on the management and resuscitation of children with septic shock and other sepsis-associated organ dysfunction. Overall, six were strong recommendations, 49 were weak recommendations, and nine were best-practice statements. For 13 questions, no recommendations could be made; but, for 10 of these,  in our practice  statements were provided. In addition, 52 research priorities were identified.
CONCLUSIONS: A large cohort of international experts was able to achieve consensus regarding many recommendations for the best care of children with sepsis, acknowledging that most aspects of care had relatively low quality of evidence resulting in the frequent issuance of weak recommendations. Despite this challenge, these recommendations regarding the management of children with septic shock and other sepsis-associated organ dysfunction provide a foundation for consistent care to improve outcomes and inform future research

Weiss, Scott L

Peters, Mark J

Flori, Heidi R

Inwald, David P

Schlapbach, Luregn J

Tasker, Robert C

Argent, Andrew C

Carrol, Enitan D

Carroll, Christopher L

Cheifetz, Ira M

Cies, Jeffry J

Cruz, Andrea T

Faust, Saul N

Hall, Mark W

Joosten, Koen F M

Kneyber, Martin C J

Mehta, Nilesh M

Newth, Christopher J L

Nguyen, Trung C

Nunnally, Mark E

Parker, Margaret M

Paul, Raina

Randolph, Adrienne G

Romer, Lewis H

Scott, Halden F

Tume, Lyvonne N

Verger, Judy T

Williams, Eric A

Wong, Hector R

Zimmerman, Jerry J

Aurora Health Care Digital Repository

Weiss, S

Peters, M

Alhazzani, W

Agus, M

Flori, H

Inwald, D

Nadel, S

Schlapback, J

Tasker, R

Argent, A

Brierley, J

Carcillo, J

Carrol, E

Carrol, C

Chiefetz, I

Choong, K

Cies, J

Cruz, A

de Luca, D

Deep, A

Faust, S

Flauzino, C

Hall, M

Ishimine, P

Javouhey, E

Joosten, K

Joshi, P

Karam, O

Knebjer, M

Lemson, J

McClaren, G

Mehta, N

Hylander, M

Newth, C

Nguyen, T

Nishisaki, A

Nunally, M

Parker, M

Paul, R

Randolph, A

Executive summary : surviving sepsis campaign international guidelines for the management of septic shock and sepsis-associated organ dysfunction in children

https://pure.eur.nl/files/42637811/Executive_Summary_Surviving_Sepsis_Campaign.11.pdf