Abdul Karim, Mohamed Ismail

Jamal, Parveen

Mel, Maizirwan

Mohamed Salleh, Mohamad Ramlan

Zakaria, Ruzi Aini

English

The International Islamic University Malaysia Repository

Taguchi Method In BioprocessEngineering:Case StudiesEdited ByMaizirwan MelNajiah NadirHUM PressPublished by:HUM PressIntemationallslamic University MalaysiaFirst Edition, 20 II© HUM Press, HUMAll rights reserved. No part of this publication may be reproduced, stored in a retrival system, or trans-mitted, in any form or by any means, electronic, mechanical, photocopying, recording or otherwise,without prior written permission of the publisher.Perpustakaan Negara MalaysiaTaguchi Method in Bioprocess Engineering: case StudiesMaizirwan Mel & Najiah NadirISBN 978-967-418-070-6Cataloguing-in-Publication DataMember ofMajlis Penerbitan Ilmiah Malaysia - MAPIM(Malaysian Scholarly Publishing Council)Printed by:HUM PRINTING SON. SHO.No. I, Jalan Industri Batu Caves 1/3,Taman Perindustrian Batu Caves,Batu Caves Centre Point,68100 Batu Caves,Selangor Darnl EhsanPREFACESYNOPSISCHAPTER1 Introduction to Taguchi MethodAlaizinl'iln Mel, Naiia!I NadirContentsv;;;x12 Design of Experiments Using Taguchi's ApproachAlaizinl'iln AIel. Naiia!I Nadir173 Taguchi Robust Design Creation by STATISTICA Software 31AIaizin1'Cln Mel, Najia!I Nadir4 Case Study 1: Process Improvement of PharmaceuticalGrade Ethanol Production 59Najia!I Nadif; Maizirwan Mel, Ma!Id Ismail Abdul Karim,R(js/i Mohd Yunus5 Case Study 2: Process Optimization of Lactic AcidProduction in FermenterMaizinran Mel, Mohd Ismail Abdul Karim, P(l/Teen.Jamal,Mohamad Ramlan Mohamed Sal/elf, Ruzi Aini Zakaria756 Case Study 3: Optimization of Coenzyme Q10 Productionin Bioreactor 89Maizirwan Mel, Molld Ismail Abdul Karim, Fairin Huda Faivdullall7 Case Study 4: Improvement of Clarification and SeparationProcess for Hybrldoma Cell Supernatant 103Maizirwan Mel, Mohd Ismail Abd Karim, F'aridah Yusul: Dzul1 Noriani,Hamadall Molld Nur Luhis .8 Taguchi on Quality ImprovementMaizinml1 Mel, Najiah Nadir1139 Case Study 5: Analysis of Process Capability andQuality of Moncsclonal Antibody Production in Bioreactor 133Maizirwan Mel, Molld Ismail Abdul Karim, Faridah YusofReferences 143ChapterCase Study 2: ProcessOptimization of Lactic AcidProduction in FermenterMuizir"'U/I !'old, M"',,J b",uif Abd,,/ Kf'Ti",. /'ur"I'O'"Jall"'/. Mlllu","''' RUII/fall M"llll"",d Suit,·" ami NII:i Ai,,;Zukuriu1. InlroductiollLadic acid is an organic acid which is widely used in the indUSlrialapplicalions, In Ihe r~'CCnl years, the in(cr~'S1 towards lactic acidI\.-.;ovcry from t(,mwnlalion broth has I>cCIl increased duc to thetkm~lnd "r pur"l)' Or Ilmur~lIy pmduc~'<J bClic acid. World demand10, lat,ti" acid is csl;m"tcd as S 150 million (100,000 lOOt'S) per year.This add can be used as a preservmive and acidul:ml in foods. as acolllrulh..'d ddiver)' 01" drugs in pharmaceutical agents. as a precursorlor production or polymer in plastic industries and as an Importantehe'm ical in leather Janning and lC;I;lilc dyeing (Swnllury and Whitaker.I'JK4). About 5U 0/. oflhe market is in food and bcvcrdgc applicationswhkh are a mature 'md ~tal:>lc mark~1 (Shuler nnd Kargi, 20(2).The productiun of lactic aeill is inlluenced by the upcmtingparameters of the rcrm<:ll1alion process ill the biorcaclor such as"per<lting lelupcrdturc. s.lmpk I'll. agilation spc~-d or the impd ler. andthe ll,ssnln'll oxygen le\lel. These parallleter.; give sigmlknnt "'leet onth" gmwth and llloetnboJie pnxluetion of 'noetic a<:id, Many studie~ hadt><:~'n perfurmed 10 uplilllize Ih~'Sc parameters in order to produce the

Case study 2: process optimization of lactic acid production in fermenter

http://irep.iium.edu.my/25033/1/Case_Study_2.pdf

Case study 2: process optimization of lactic acid production in fermenter

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