Arifin, Mohd Azmir

Mel, Maizirwan

Salim, Siti Hajar

The International Islamic University Malaysia Repository

Chapter 16Newcastle Disease Virus Propagationin Stirred Tank Bioreactor: Part IMultdA:;mir Arijill, Sit; Hujur Su/illl• .'Hui:irll'un ,lidI. IntroductionNewcastle disease (1'.'1)). caused by Newcastle d,scase \'irus (NDV)is reponed as lhc most imponam viral disease of poultry m the worldIAdene. 1990). NO has been a dc\-astaling disease of pouhry. andin many countries the disease remains olle of the major problemsatfecting exisling ur developing poultry industries. The disease- canvary from clinically inaplXln:nllO highly vimlcn! forms. depending onIhe virus ~trnin and lhe llos1 spa;ics{lluang <'f al.. 2003). NDV belongsto the Avula,'iros g",nU5 wilhin Ihc family I'aramysoviridac. subfamilyParamyxul'irinac. in the order Mononcga,'iralcs and is dcsignalctl3\ ian paramyxo\'irus-l (ArMV-I). Nine avian paramy.~o,·irusscrolypes IArMV-1 to APMV-9). of whi<:h ArMV_1 is the mostc<:onomically imponam. have been i<1cntified amnng Ihese vin'slypcs (Ale.~ander. 2003). The en\'c10IX-d \'irus has a negati'·e-scnse.single,slwnde<1 RNA genome "hich cOOes for six proteins includinga nucleoprotein (N). phosphoprotein (P). mmrix (M) protein. fusion(1'1 prot<:in. hClTlagglutinin.neuraminidase (fIN) protein and an RNA<1irecte<1 RNA polymerase ILl in the 30 to 50 direction (<1e Lecuw

Newcastle Disease virus propagation in stirred tank bioreactor: part I

http://irep.iium.edu.my/16979/8/Newcatles_Disease_Virus_1.pdf

Newcastle Disease virus propagation in stirred tank bioreactor: part I

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