착용할 수 있는 생체 감지 전극과 무선으로 연결된 마이크로 바늘 패치로 구성된 인공적인 항상성 조절 시스템

Abstract

학위논문 (석사)-- 서울대학교 대학원 : 공과대학 화학생물공학부, 2018. 2. 김대형.Homeostasis state regulation is the major role of human nerve and endocrine systems. Several factors such as blood glucose, cortisol hormone levels, electrolyte levels, and body temperature are detected and controlled by these systems. However, failure of human endocrine system causes many chronic diseases such as diabetes, depression, and high fever. Here, bio-inspired wireless platform integrated with wearable biosensor, smartphone networking, and wearable microneedle patch was proposed for artificial homeostasis regulation. Direct electron transfer (DET) electrode have been developed for wearable biosensor using vertically aligned carbon nanotube (VACNT)-graphene (GP)-Au mesh structure for accurate biomarker detection from sweat. In addition, the drug-loaded microneedle is attached with wearable heater patch, enabling transdermal drug delivery with the sensor detection for closed-loop feedback. Finally, all these components are controlled by user-friendly smartphone application that mimic the human nerve system. Artificial regulation platform of human homeostasis provides a helpful tool for preventing chronic disease.1. Introduction . 11 2. Wearable electrochemical biosensors based on DET electrode. 15 2.1 Fabrication of wearable biosensors and characterization of DET electrode 15 2.2 Glucose, cortisol, potassium, temperature sensor based on DET electrode. 19 2.3 User-friendly data sharing with smartphone application. 27 3. Wirelessly-interconnected wearable microneedle patch. 31 3.1 Design and characterization of wearable microneedle patch actuator. 31 3.2 Characterization of wearable microneedle patch. 33 3.3 In vitro drug release test using actuator. 36 3.4 In vivo drug delivery to various type mice 41 4. Experimental section. 44 4.1 Fabrication process of wearable electrochemical biosensors. 44 4.2 Material analysis of DET electrode 44 4.3 Preparation of the electrochemical sensors. 45 4.4 Fabrication process of wearable heater. 47 4.5 Fabrication process of drug-loaded microneedle 47 5. Conclusion. 49 6. References 50Maste