극한 환경에서 서식하는 미생물로부터 분리한 polyketide에서 유래된 새로운 이차대사물질의 구조 규명

Abstract

학위논문 (석사)-- 서울대학교 대학원 : 약학대학 약학과, 2017. 2. 오동찬.Bacteria inhabiting extreme environments have been considered as attracting resources for bioactive compounds. As part of continuing efforts to explore the chemical diversity of bacteria from extreme habitats for drug discovery, in this study, bacterial strains inhabiting saltern and Alaskan permafrost have been investigated. Actinobacterial strains were isolated from these extreme habitats, cultivated, and chemically analyzed by LC/MS. Based on the bacterial chemical profiles acquired by LC/MS analysis, four new polyketide-derived compounds including three new macrolides and an oxazole-bearing compound were discovered. The structures of the new natural products were elucidated by the analysis of spectroscopic data such as 1D and 2D NMR, mass, UV, and IR spectra.Introduction 1 Ⅰ. Borrelidins C-E, new macrolide compounds from a halophilic Nocardiopsis sp.actinobacterium 3 Ⅱ. TD3-468, new 26-membered oxazole-polyene compound from a psychrophilic Streptomyces sp. 23 References 31 Appendix: NMR spectroscopic data 32 Abstract in Korean 51Maste