Quantitative Analysis of Pulsatile Flow Contribution to Ultrafiltration

Abstract

We evaluated the quantitative contribution of pulsatile flow to ultrafiltration (UF) in terms of fluid power, membrane stretch, and reduction of membrane layering. An in vitro comparison of the UF rate using pulsatile and roller pumps was performed with distilled water and bovine whole blood. The mean transmembrane pressure (TMPm) and UF rate were higher with the pulsatile pump for the same mean flow rate: 6.6 mm Hg and 21.1 mL/min higher on average for distilled water and 34.2 mm Hg and 31.4 mL/min higher on average for blood. The average UF rate was 8.4 mL/min higher with the pulsatile pump for the same TMPm with bovine blood. However, the relationship between the UF rate and the TMPm was independent of the flow configuration for distilled water. We showed that the higher UF rate in the pulsatile pump is mainly due to greater fluid power and reduction of membrane layering, while the membrane stretch was not an important factor.This work was supported by Korea Science & Engineering Foundation through the NRL program (ROA-2008-000-20127-0).HERCE JL, 2006, ARTIF ORGANS, V30, P64Ruperez M, 2005, ASAIO J, V51, P372ZAMIR M, 2005, PHYS CORONARY BLOOD, P36DENPNER T, 2004, REPLACEMENT RENAL FU, P73Pedrini LA, 2003, KIDNEY INT, V64, P1505Ruperez M, 2003, PEDIATR NEPHROL, V18, P29, DOI 10.1007/s00467-002-0991-2Salifu MO, 2001, ASAIO J, V47, P389Schmidt R, 2001, NEPHROL DIAL TRANSPL, V16, P595Miwa M, 1999, ARTIF ORGANS, V23, P1123Morti SM, 1998, ASAIO J, V44, P319RUNGE TM, 1993, INT J ARTIF ORGANS, V16, P645LEONG ASY, 1982, NEW ENGL J MED, V306, P135BOMMER J, 1981, LANCET, V1, P1314