This study compared the biocompatibility of two new calcium phosphate-based root canal sealers (CAPSEAL I, CAPSEAL II) with another type of commercially available calcium phosphate sealer (Apatite Root Sealer type I, Apatite Root Sealer type II) and a zinc oxide eugenol-based sealer (Pulp Canal Sealer EWT) after implanting them in the subcutaneous tissue of rats. After 1, 2, 4, and 12 weeks, the tubes were removed with the surrounding tissues. The tissue reactions were graded as being mild or
1, moderate or 2, and severe or 3 after a histopathological
examination. The results were analyzed
statistically with the Kruskal-Wallis test. The
biocompatibility of the materials was interpreted
according to the Federation Dentaire Internationale
criteria (1980). The inflammatory reactions decreased
with time. The new sealers showed a
lower tissue response than any of the other sealers
in all the experimental periods. All the tested sealers
showed an acceptable biocompatibility.This study was supported by a grant from Korea Health 21 R&D Project, Ministry of Health and Welfare, Republic of Korea (01-PJ5-PG1β01CH12β0002)