한국생화학분자생물학회 = Korean Society for Biochemistry and Molecular Biology
Abstract
Peroxisome proliferator-activated receptor α and estrogen are
believed to be involved in metabolic changes leading to obesity.
To test this relationship, we divided female wildtype and
PPARα-deficient mice fed on a high fat diet into the following
groups: mock-operated, ovariectomized (OVX), and E2-treated.
The visceral white adipose tissue and plasma cholesterol levels
were increased significantly in wild type OVX and decreased in
the E2-treated group, but interestingly not in PPARα-deficient
mice. The mRNA levels of lipoprotein lipase in adipose tissue
were also increased in only wild type OVX and decreased significantly
in E2-treated mice. These novel results suggest the possibility
of signaling crosstalk between PPARα and E2, causing
obesity in vivo.This work was supported by a grant from the Korean Ministry
of Heath and Welfare (A000385) and a grant from the Seoul R
& BD Program (11117M0214882)
