Fingerprint deposits have been considered as a characteristic feature of lupus
nephritis. We report such deposits in a case with hepatitis B virus-associated
membranoproliferative glomerulonephritis. The patient did not show any sign of systemic
lupus erythematosus at time of biopsy or during a 3· year follow-up period

Kang, Gyeong Hoon

Lee, Hyun Soon

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The Seou! Journal of MedicineVol. 33. Nil. I 73-77, Murch ICJI)~Glomerular Fingerprint DepositsIn Hepatitis 8 Virus-associated Nephropathy tGyeong Hoon Kang and Hyun Soon Lee'Depornncnt of Pathology. Scou! National U niversit v College of Medicine, Seoul llO-460, Korea=Abstract=Fingerprint deposits have been considered as a characteristic feature of lu-pus nephritis. We report such deposits in a case with hepatitis B virus-associatedmembranoproliferative glomerulonephritis. The patient did not show any sign of sys-temic lupus erythematosus at time of biopsy or during a 3· year follow-up period.Key Words: Fingerprint deposits, Hepatitis B virus infection, MembranoproliferativeglomcrulonephritisINTRODUCTIONSince Grishman et al. (1967) reportedorganized deposits with a fingerprint pattern inkidneys with systemic lupus erythematosus(SLE), they have been regarded as a rare butspecial ultrastructural feature of lupus neph-ritis. Yet, these deposits were also described ina few cases with idiopathic membranousnephropathy (Spargo et al. 1980), membrano-proliferative glomerulonephritis (MPGN) (Daviset al. 1976), and Goodpasture's syndrome(Zollinger et al. 1978). Alpers et al. (1984)reported two patients featuring glomerulardeposits with a fingerprint pattern, who did notshow any evidence of SLE at time of biopsybut later developed clinical features of SLE.From thses observations, they believe thatthese deposits can be a specific marker forSLE, even when overt clinical signs of SLE areReceived January 1992, and in final form March1992.t This wnrk was supported by a grant from SeoulNational University Hospita] (19R9).I Author for correspondence;.,i ·9- el19)' .1'" S!].iZ1 [11 ~l Iii t.,] ~). ~ll Al . '1).'J-! ."5. 6]-&,1-",,,,~ ~ \ 1 - r n 1 O 1 --' - 2.. 0 0 1l , , 1_ tz.,absent.We have observed such deposits in renalbiopsy material from a patient with hepatitis Bvirus (HBV)-associated MPGN, who did notshow any sign of SLE at time of biopsy or aftera follow-up of three years. The extreme rarity ofthis lesion in renal disease with no evidence ofSLE prompted us to report this case. Also, wewill discuss the possible pathogenesis of thislesion in this report.CASE REPORTA 55-year-old woman was admitted in Au-gust 1988 for evaluation of generalized edemaand left flank pain. The edema had begun fouryears previously, when urinary abn6rmalitieshad been detected. She had been intermittentlytreated with diuretics. Physical examinationrevealed a slight degree of pitting edema inboth extremities. Blood pressure was 160/110mmHg. All other systems were normal. The lab-oratory investigation included the following:hemoglobin 13.6 g/dL, leukocyte count7,500/mm 3 , platelet count 310,000/mm 3 , bloodurea nitrogen 4.6 mmol/L urea (13 mq/dl.].creatinine 71 .umol/L (0.8 rnq/dl.), SGOT 25units/L, SGPT 26 units/L, albumin 2.7 g/dL,

Glomerular Fingerprint Deposits In Hepatitis B Virus-associated Nephropathy

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Glomerular Fingerprint Deposits In Hepatitis B Virus-associated Nephropathy

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