Defective neutrophil function in workers occupationally exposed to hexachlorobenzene

Abstract

In this work rye have studied the respiratory burst and chemotaxis of polymorphonuclear leukocytes from 51 workers exposed to chlorinated compounds, which were compared with those of non-exposed, age- and sex-matched invididuals. These two neutrophil functions were significantly reduced as compared to controls. No correlation was observed between the length of exposures, hexachlorobenzene (HCB) blood concentrations and neutrophil chemotaxis or the extent of nitroblue tetrazolium reduction.16632232