Synthesis of some novel pyrido[2,3-<i>d</i>]pyrimidine derivatives and their antimicrobial investigations

Abstract

448-452A series of pyrido[2,3-d]pyrimidine derivatives viz 4-amino-5,7-disubstituted pyrido[2,3-d]pyrimidines 3a-d, 4-amino-5,7-disubstituted pyrido[2,3-d]pyrimidin-2(1H)-ones 4a-d and 4-amino-5,7-disubstituted pyrido[2,3-d]pyrimidin-2(1H)-thione 5a-d have been synthesized by the condensation reaction of 2-amino-3-cyano-4,6-disubstituted pyridines 2a-d with formamide, urea and thiourea, respectively. The newly synthesized compounds have been established by elemental analysis, IR, 1H and 13C NMR. All the synthesized compounds have been screened for their antibacterial and antifungal activity