The α-MnO2 nanorods (MnO2 NR) were first synthesized and then incorporated onto the basal plane of reduced graphene oxide (RGO) with the aid of ultrasonication to obtain a composite (MnO2 NR/RGO). A novel modified electrode (MnO2 NR/RGO/GCE) based on the MnO2 NR/RGO composite was fabricated and used for the selective detection of uric acid (UA) in the mass of ascorbic acid (AA). The as-made modified electrode shows a good electron transfer ability and displays a novel performance for the detection of UA. More interestingly, this electrode can effectively eliminate the interference of AA. A linear dependence on the concentration of UA from 5 × 10-8 to 4 × 10-4 M was measured by differential pulse voltammetry (DPV), and the detection limit was up to 1 × 10-8 M. The good sensitivity and repeatability of the proposed electrode enabled its successful application for the selective determination of UA in human urine sample analysis. These results will enhance our understanding of the applicability of MnO2 NR/RGO in electrochemical analysis
