Ligand-Activated Peroxisome Proliferator-Activated Receptor-  Protects Against Ischemic Cerebral Infarction and Neuronal Apoptosis by 14-3-3  Upregulation

Chen, Jin Jer; Chen, Y. Eugene; Chen, Yi Tong; Chen, Yu Chang; Cheung, Wai Mui; Fong, Wen Hsuan; Lin, Teng Nan; Liou, Jun Yang; Maeda, Nobuyo; Shyue, Song Kun; Tsai, Hsin Da; Tsai, Yau Sheng; Wu, Jui Sheng; Wu, Kenneth K.

Ligand-Activated Peroxisome Proliferator-Activated Receptor- Protects Against Ischemic Cerebral Infarction and Neuronal Apoptosis by 14-3-3 Upregulation

Authors: Jin Jer Chen
Y. Eugene Chen
Yi Tong Chen
Yu Chang Chen
Wai Mui Cheung
Wen Hsuan Fong
Teng Nan Lin
Jun Yang Liou
Nobuyo Maeda
Song Kun Shyue
Hsin Da Tsai
Yau Sheng Tsai
Jui Sheng Wu
Kenneth K. Wu
Publication date: 1 January 2009
Publisher
Doi

Abstract

Thiazolidinediones (TZD) were reported to protect against ischemia-reperfusion (I/R) injury. Their protective actions are considered to be PPAR-γ (peroxisome proliferator-activated receptor γ)-dependent. However, it is unclear how PPAR-γ activation confers resistance to I/R

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