Genome-wide linkage analysis of 1,233 prostate cancer pedigrees from the International Consortium for prostate cancer Genetics using novel sumLINK and sumLOD analyses

Badzioch, Michael D.; Baffoe-Bonnie, Agnes B.; Bailey-Wilson, Joan E.; Carpten, John D.; Christensen, G. Bryce; Deutsch, Kerry; Dimitrov, Latchezar; Easton, Douglas; Eeles, Ros; English, Dallas R.; Foulkes, William D.; George, Asha; Giles, Graham G.; Hopper, John L.; Hsieh, Chih-Lin; Isaacs, Sarah D.; Isaacs, William B.; Johanneson, Bo; Maehle, Lovise; McDonnell, Shannon K.; McIntosh, Laura; Moller, Pal; Oakley-Girvan, Ingrid; Ostrander, Elaine A.; Powell, Isaac; Severi, Gianluca; Stanford, Janet L.; Thibodeau, Stephen N.; Walsh, Patrick C.; Whittemore, Alice S.; Wiley, Kathleen E.; Xu, Jianfeng

Genome-wide linkage analysis of 1,233 prostate cancer pedigrees from the International Consortium for prostate cancer Genetics using novel sumLINK and sumLOD analyses

Abstract

Prostate cancer is generally believed to have a strong inherited component, but the search for susceptibility genes has been hindered by the effects of genetic heterogeneity. The recently developed sumLINK and sumLOD statistics are powerful tools for linkage analysis in the presence of heterogeneity

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Last time updated on 24/11/2020