Mechanisms of Oral Tolerance

Abstract

Oral tolerance is an active process of local and systemic immune unresponsiveness to orally ingested antigens such as food. The gut immune system must balance responses to commensal bacteria (microbiome), innocuous antigens and pathogens. While it is clear that specialized populations immune cells and lymph nodes create a unique environment in the gut, there remains evidence to suggest that systemic effector sites are also critical to establishing and maintaining oral tolerance

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