Thrombus formation can occur in both macroscopic and microscopic blood vessels. In the brain, cerebral venous sinus thrombosis (CVST) and focal cortical infarctions can result from the formation of thrombi in these different sized vessels. In this study we define the relative contributions of three major pro- and anti-coagulation pathways (heparin-antithrombin, protein C, and tissue factor (TF)) in the thrombogenic responses that occur in large and small vessels of the brain
