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Region-Specific Microstructure in the Neonatal Ventricles of a Porcine Model
Authors
A Bassols
A Lander
+45 more
A Palit
A Palit
A Rudolph
AH Cheema
AM Rudolph
B Wang
CP Twine
E Petrossian
F. Ahmad
FA Tibayan
G Sommer
H Kurobe
H Liu
H Liu
I. Khan
I. Maconochie
J. Liao
JG Malcolm
JI Hoffman
KT Weber
L Zhang
LA Taber
M Samanek
M. Jones
ML Burgess
MP Bal
N Reznikov
N Reznikov
N. White
P Vodicka
Peter Theobald
PJ Campagnola
PJ Campagnola
R. Johnston
R. Prabhu
S Zhang
S. Soe
SA Book
SJ Crick
T Tirilomis
TS Eriksson
V Caorsi
WJ Karlon
X Wang
ZQ Liu
Publication date
1 January 2018
Publisher
'Springer Science and Business Media LLC'
Doi
Cite
Abstract
© 2018, Biomedical Engineering Society. The neonate transitions from placenta-derived oxygen, to supply from the pulmonary system, moments after birth. This requires a series of structural developments to divert more blood through the right heart and onto the lungs, with the tissue quickly remodelling to the changing ventricular workload. In some cases, however, the heart structure does not fully develop causing poor circulation and inefficient oxygenation, which is associated with an increase in mortality and morbidity. This study focuses on developing an enhanced knowledge of the 1-day old heart, quantifying the region-specific microstructural parameters of the tissue. This will enable more accurate mathematical and computational simulations of the young heart. Hearts were dissected from 12, 1-day-old deceased Yorkshire piglets (mass: 2.1–2.4kg, length: 0.38–0.51m), acquired from a breeding farm. Evans blue dye was used to label the heart equator and to demarcate the left and right ventricle free walls. Two hearts were used for three-dimensional diffusion-tensor magnetic resonance imaging, to quantify the fractional anisotropy (FA). The remaining hearts were used for two-photon excited fluorescence and second-harmonic generation microscopy, to quantify the cardiomyocyte and collagen fibril structures within the anterior and posterior aspects of the right and left ventricles. FA varied significantly across both ventricles, with the greatest in the equatorial region, followed by the base and apex. The FA in each right ventricular region was statistically greater than that in the left. Cardiomyocyte and collagen fibre rotation was greatest in the anterior wall of both ventricles, with less dispersion when compared to the posterior walls. In defining these key parameters, this study provides a valuable insight into the 1-day-old heart that will provide a valuable platform for further investigation the normal and abnormal heart using mathematical and computational models
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