Opiate use is common in HIV- and hepatitis C virus (HCV)-infected individuals, however its contribution to the risk of diabetes mellitus is not well understood

Anastos, Kathryn

Augenbraun, Michael

Cohen, Mardge H

Cole, Stephen R

Hoover, Donald R

Howard, Andrea A

Kovacs, Andrea

Latham, Patricia S

Shi, Qiuhu

Strickler, Howard D

Tien, Phyllis C

Wu, Xi

PubMed

Carolina Digital Repository

The Effects of Opiate Use and Hepatitis C Virus Infection on Risk of Diabetes Mellitus in the Womenʼs Interagency HIV Study

BACKGROUND: Opiate use is common in HIV-infected and hepatitis C virus (HCV)-infected individuals, however, its contribution to the risk of diabetes mellitus is not well understood. METHODS: Prospective study of 1713 HIV-infected and 652 HIV-uninfected participants from the Women\u27s Interagency HIV Study between October 2000 and March 2006. Diabetes defined as fasting glucose ≥126 mg/dL, self report of diabetes medication use, or confirmed diabetes diagnosis. Opiate use determined using an interviewer-administered questionnaire. Detectable plasma HCV RNA confirmed HCV infection. RESULTS: Current opiate users had a higher prevalence of diabetes (15%) than nonusers (10%, P = 0.03), and a higher risk of incident diabetes (adjusted relative hazard: 1.58, 95% confidence interval: 1.01 to 2.46), after controlling for HCV infection, HIV/antiretroviral therapy status, and diabetes risk factors including age, race/ethnicity, family history of diabetes, and body mass index. HCV infection was also an independent risk factor for diabetes (adjusted relative hazard: 1.61, 95% confidence interval: 1.02 to 2.52). HCV-infected women reporting current opiate use had the highest diabetes incidence (4.83 cases per 100 person-years). CONCLUSIONS: Among women with or at-risk for HIV, opiate use is associated with increased diabetes risk independently of HCV infection. Diabetic screening should be part of care for opiate users and those infected with HCV. © 2010 Lippincott Williams & Wilkins

Howard, Andrea A.

Hoover, Donald R.

Strickler, Howard D.

Cole, Stephen R.

Cohen, Mardge H.

Latham, Patricia S.

Tien, Phyllis C.

George Washington University: Health Sciences Research Commons (HSRC)

The effects of opiate use and hepatitis c virus infection on risk of diabetes mellitus in the women\u27s interagency HIV study

https://cdr.lib.unc.edu/downloads/xw42ng21b

The Effects of Opiate Use and Hepatitis C Virus Infection on Risk of Diabetes Mellitus in the Womenʼs Interagency HIV Study

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George Washington University: Health Sciences Research Commons (HSRC)