Introducing flood control to an area of endemic waterborne diseases could have significant impacts on spatio-temporal occurrence of cholera. Using 21-years of data from Bangladesh, we conducted cluster analysis to explore changes in spatial and temporal distribution of cholera incidence since construction of flood control structures. Striking changes in temporal cluster patterns emerged, including a shift from dry season to rainy season clusters following flood protection and delayed clustering inside the protected areas. Spatial differences in pre-flood protection and post-protection cholera clusters are weaker. Changes in spatio-temporal cholera clustering, associated with implementation of flood protection strategies, could affect local cholera prevention efforts
