Genetic Variation in TYMS in the One-Carbon Transfer Pathway Is Associated with Ovarian Carcinoma Types in the Ovarian Cancer Association Consortium

Anton-Culver, Hoda; Beesley, Jonathan; Berchuck, Andrew; Brar, Sony; Carney, Michael E; Chang-Claude, Jenny; Chenevix-Trench, Georgia; Cramer, Daniel W; Cunningham, Julie M; DiCioccio, Richard A; Doherty, Jennifer A.; Easton, Douglas F; Fredericksen, Zachary S; Fridley, Brooke L; Gates, Margaret A; Gayther, Simon A; Gentry-Maharaj, Aleksandra; Goode, Ellen L; Goodman, Marc T; Høgdall, Estrid; Kelemen, Linda E; Kjær, Susanne Krüger; Köbel, Martin; Lurie, Galina; McGuire, Valerie; Menon, Usha; Moorman, Patricia G; Moysich, Kirsten; Ness, Roberta B; Palmieri, Rachel T; Pearce, Celeste L; Pharoah, Paul DP; Ramus, Susan J; Rossing, Mary Anne; Schildkraut, Joellen M; Sellers, Thomas A; Song, Honglin; Stram, Daniel O; Tworoger, Shelley S; Van Den Berg, David; Vierkant, Robert A; Wang-Gohrke, Shan; Webb, Penelope M; Whittemore, Alice S; Wilkens, Lynne R; Wu, Anna H

Genetic Variation in TYMS in the One-Carbon Transfer Pathway Is Associated with Ovarian Carcinoma Types in the Ovarian Cancer Association Consortium

Abstract

We previously reported risks of ovarian carcinoma for common polymorphisms in one-carbon (1-C) transfer genes. We sought to replicate associations for DPYD rs1801265, DNMT3A rs13420827, MTHFD1 rs1950902, MTHFS rs17284990 and TYMS rs495139 with risk of ovarian carcinoma overall, and to utilize the large sample of assembled cases to investigate associations by histological type

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