Association of the Colorectal CpG Island Methylator Phenotype with Molecular Features, Risk Factors, and Family History

Ahnen, Dennis J.; Bapat, Bharati; Baron, John A.; Buchanan, Daniel D.; Campbell, Peter T.; Casey, Graham; Clendenning, Mark; Daftary, Darshana; Gallinger, Steven; Haile, Robert W.; Hopper, John L.; Joshi, Amit D.; Laird, Peter W.; Le Marchand, Loic; Levine, A. Joan; Lindor, Noralane M.; Long, Tiffany I.; Newcomb, Polly A.; Rosty, Christophe; Selander, Teresa; Siegmund, Kimberly D.; Stern, Mariana C.; Walters, Rhiannon; Weisenberger, Daniel J.; Young, Joanne P.

Association of the Colorectal CpG Island Methylator Phenotype with Molecular Features, Risk Factors, and Family History

Abstract

The CpG Island Methylator Phenotype (CIMP) represents a subset of colorectal cancers (CRCs) characterized by widespread aberrant DNA hypermethylation at select CpG islands. The risk factors and environmental exposures contributing to etiologic heterogeneity between CIMP and non-CIMP tumors are not known

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Last time updated on 24/11/2020