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Quality of life in patients treated with first-line antiretroviral therapy containing nevirapine or efavirenz in Uganda: A prospective non-randomized study
Authors
A Casado
A Deribew
+56 more
A Stangl
A Stangl
A Tesfay
Achilles Katamba
AL Stangl
Albert W. Wu
AR Tarlov
B Nirmal
C Fumaz
C Goujard
C Shumba
D Mutabazi-Mwesigire
D Tate
DA Revicki
Doris Mutabazi Mwesigire
E Negredo
EJ Mills
F Kaharuza
F Leth Van
F Leth Van
F Martin
Faith Martin
FE Harrell
G Samsa
H Jia
J Cohen
J Côté
J Jelsma
J Pitt
J-J Parienti
Janet Seeley
JB Nachega
JH Arnsten
JH Oyugi
KW Crawford
L Radloff
M Berg-Wolf Van den
M Hartmann
M Poupard
N Nakasujja
P Barreiro
P Beaudrap De
P Bock
P Pillay
P-Y Chiou
R Bucciardini
R Cummins
R Patel
R Sangeda
RS Braithwaite
S Haïm-Boukobza
S Kanters
SB Mannheimer
T Mast
WA Wu
Z Shubber
Publication date
1 January 2015
Publisher
'Springer Science and Business Media LLC'
Doi
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PubMed
Abstract
© 2015 Mwesigire et al. Background: The goal of antiretroviral therapy (ART) is to suppress viral replication, reduce morbidity and mortality, and improve quality of life (QoL). For resource-limited settings, the World Health Organization recommends a first-line regimen of two-nucleoside reverse-transcriptase inhibitors and one non-nucleoside transcriptase inhibitor (nevirapine (NVP) or efavirenz (EFV)). There are few data comparing the QoL impact of NVP versus EFV. This study assessed the change in QoL and factors associated with QoL among HIV patients receiving ART regimens based on EFV or NVP. Methods: We enrolled 640 people with HIV eligible for ART who received regimens including either NVP or EFV. QoL was assessed at baseline, three months and six months using Physical Health Summary (PHS) and Mental Health Summary (MHS) scores and the Global Person Generated Index (GPGI). Data were analyzed using generalized estimating equations, with ART regimen as the primary exposure, to identify associations between patient and disease factors and QoL. Results: QoL increased on ART. The mean QoL scores did not differ significantly for regimens based on NVP versus EFV during follow-up for MHS and GPGI regardless of CD4 stratum and for PHS among patients with a CD4 count >250 cells/μL. The PHS-adjusted β coefficients for ART regimens based on EFV versus NVP by CD4 count strata were as follows: -1.61 (95 % CI -2.74, -0.49) for CD4 count 250 cells/μL. The corresponding MHS-adjusted β coefficients were as follows: -0.39 (-1.40, 0.62) for CD4∈250 cells/μL. The GPGI-adjusted odds ratios for EFV versus NVP were 0.51 (0.25, 1.04) for CD4 count ∈250 cells/μL. QoL improved among patients on EFV over the 6-month follow-up period (MHS p
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