Platelet-Endothelial Cell Adhesion Molecule-1 Regulates Endothelial NO Synthase Activity and Localization Through Signal Transducers and Activators of Transcription 3-Dependent NOSTRIN Expression
Nitric oxide (NO) produced by the endothelial NO synthase (eNOS) is an important regulator of cardiovascular physiology and pathology. eNOS is activated by numerous stimuli and its activity is tightly regulated. Platelet-endothelial cell adhesion molecule-1 (PECAM-1) has been implicated in regulating eNOS activity in response to shear stress. The goal of the current study is to determine the role of PECAM-1 in the regulation of basal eNOS activity
