To compare the rates of gestational diabetes (GDM) among women who received serial doses of 17 alpha hydroxyprogesterone caproate (17-OHPC) versus placebo

Caritis, Steve N.

Carpenter, Marshall W.

Conway, Deborah

Dombrowski, Mitchell

Gyamfi, Cynthia

Horton, Amanda L.

Iams, Jay D.

Lo, Julie

Meis, Paul J.

Mercer, Brian M.

Miodovnik, Menachem

Momirova, Valerija

O'Sullivan, Mary Jo

Peaceman, Alan M.

Ramin, Susan M.

Rouse, Dwight J.

Sciscione, Anthony

Sibai, Baha

Spong, Catherine Y.

Varner, Michael W.

American Journal of Obstetrics and Gynecology

PubMed

Carolina Digital Repository

The effect of 17-alpha hydroxyprogesterone caproate on the risk of gestational diabetes in singleton or twin pregnancies

To compare the rates of gestational diabetes among women who received serial doses of 17-alpha hydroxyprogesterone caproate vs placebo.
Secondary analysis of 2 double-blind randomized placebo-controlled trials of 17-alpha hydroxyprogesterone caproate given to women at risk for preterm delivery. The incidence of gestational diabetes was compared between women who received 17-alpha hydroxyprogesterone caproate or placebo.
We included 1094 women; 441 had singleton and 653 had twin gestations. Combining the 2 studies, 616 received 17-alpha hydroxyprogesterone caproate and 478 received placebo. Among singleton and twin pregnancies, rates of gestational diabetes were similar in women receiving 17-alpha hydroxyprogesterone caproate vs placebo (5.8% vs 4.7%;
P = .64 and 7.4% vs 7.6%;
P = .94, respectively). In the multivariable model, progesterone was not associated with gestational diabetes (adjusted odds ratio, 1.04; 95% confidence interval, 0.62–1.73).
Weekly administration of 17-alpha hydroxyprogesterone caproate is not associated with higher rates of gestational diabetes in either singleton or twin pregnancies

Gyamfi, Cynthia

Horton, Amanda L

Momirova, Valerija

Rouse, Dwight J

Caritis, Steve N

Peaceman, Alan M

Sciscione, Anthony

Meis, Paul J

Spong, Catherine Y

Dombrowski, Mitchell

Sibai, Baha

Varner, Michael W

Iams, Jay D

Mercer, Brian M

Carpenter, Marshall W

Lo, Julie

Ramin, Susan M

O'Sullivan, Mary Jo

Miodovnik, Menachem

Conway, Deborah

University of Miami: Scholarship Miami

https://cdr.lib.unc.edu/downloads/vx021n01c

The effect of 17-alpha hydroxyprogesterone caproate on the risk of gestational diabetes in singleton or twin pregnancies

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Carolina Digital Repository

University of Miami: Scholarship Miami