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Prevalence of drug-resistant minority variants in untreated HIV-1-infected individuals with and those without transmitted drug resistance detected by sanger sequencing
Authors
D.S. Clutter
W.J. Fessel
+11 more
S.P. Holmes
L.B. Hurley
D.B. Klein
B.A. Pinsky
S.-Y. Rhee
R.W. Shafer
M.J. Silverberg
E. Spielvogel
R. Swanstrom
V. Varghese
S. Zhou
Publication date
1 January 2017
Publisher
'Oxford University Press (OUP)'
Abstract
Minority variant human immunodeficiency virus type 1 (HIV-1) nonnucleoside reverse transcriptase inhibitor (NNRTI) resistance mutations are associated with an increased risk of virological failure during treatment with NNRTI-containing regimens. To determine whether individuals to whom variants with isolated NNRTI-associated drug resistance were transmitted are at increased risk of virological failure during treatment with a non-NNRTI-containing regimen, we identified minority variant resistance mutations in 33 individuals with isolated NNRTI-associated transmitted drug resistance and 49 matched controls. We found similar proportions of overall and nucleoside reverse transcriptase inhibitor-associated minority variant resistance mutations in both groups, suggesting that isolated NNRTI-associated transmitted drug resistance may not be a risk factor for virological failure during treatment with a non-NNRTI-containing regimen. © The Author 2017. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved
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Last time updated on 24/11/2020