Little is known about arsenic and diabetes in youth. We examined the association of arsenic with type 1 and type 2 diabetes in the SEARCH for Diabetes in Youth Case-Control (SEARCH-CC) study. Because one-carbon metabolism can influence arsenic metabolism, we also evaluated the potential interaction of folate and vitamin B12 with arsenic metabolism on the odds of diabetes

Adgate, John L.

Bell, Ronny A.

Dabelea, Dana

Douillet, Christelle

Drobná, Zuzana

Grau-Pérez, Maria

Hamman, Richard F.

Knowler, William C.

Kuo, Chin-Chi

Liese, Angela D.

Mayer-Davis, Elizabeth J.

Mendez, Michelle A.

Miller, Frederick W.

Navas-Acien, Ana

Spratlen, Miranda

Styblo, Miroslav

Thayer, Kristina A.

Zhang, Chongben

Diabetes Care

English

PubMed


                  OBJECTIVE
                  Little is known about arsenic and diabetes in youth. We examined the association of arsenic with type 1 and type 2 diabetes in the SEARCH for Diabetes in Youth Case-Control (SEARCH-CC) study. Because one-carbon metabolism can influence arsenic metabolism, we also evaluated the potential interaction of folate and vitamin B12 with arsenic metabolism on the odds of diabetes.
               
               
                  RESEARCH DESIGN AND METHODS
                  Six hundred eighty-eight participants &amp;lt;22 years of age (429 with type 1 diabetes, 85 with type 2 diabetes, and 174 control participants) were evaluated. Arsenic species (inorganic arsenic [iAs], monomethylated arsenic [MMA], dimethylated arsenic [DMA]), and one-carbon metabolism biomarkers (folate and vitamin B12) were measured in plasma. We used the sum of iAs, MMA, and DMA (∑As) and the individual species as biomarkers of arsenic concentrations and the relative proportions of the species over their sum (iAs%, MMA%, DMA%) as biomarkers of arsenic metabolism.
               
               
                  RESULTS
                  Median ∑As, iAs%, MMA%, and DMA% were 83.1 ng/L, 63.4%, 10.3%, and 25.2%, respectively. ∑As was not associated with either type of diabetes. The fully adjusted odds ratios (95% CI), rescaled to compare a difference in levels corresponding to the interquartile range of iAs%, MMA%, and DMA%, were 0.68 (0.50–0.91), 1.33 (1.02–1.74), and 1.28 (1.01–1.63), respectively, for type 1 diabetes and 0.82 (0.48–1.39), 1.09 (0.65–1.82), and 1.17 (0.77–1.77), respectively, for type 2 diabetes. In interaction analysis, the odds ratio of type 1 diabetes by MMA% was 1.80 (1.25–2.58) and 0.98 (0.70–1.38) for participants with plasma folate levels above and below the median (P for interaction = 0.02), respectively.
               
               
                  CONCLUSIONS
                  Low iAs% versus high MMA% and DMA% was associated with a higher odds of type 1 diabetes, with a potential interaction by folate levels. These data support further research on the role of arsenic metabolism in type 1 diabetes, including the interplay with one-carbon metabolism biomarkers.
               </jats:sec

Maria Grau-Pérez

Chin-Chi Kuo

Miranda Spratlen

Kristina A. Thayer

Michelle A. Mendez

Richard F. Hamman

Dana Dabelea

John L. Adgate

William C. Knowler

Ronny A. Bell

Frederick W. Miller

Angela D. Liese

Chongben Zhang

Christelle Douillet

Zuzana Drobná

Elizabeth J. Mayer-Davis

Miroslav Styblo

Ana Navas-Acien

Crossref

The Association of Arsenic Exposure and Metabolism With Type 1 and Type 2 Diabetes in Youth: The SEARCH Case-Control Study

Carolina Digital Repository

The Association of Arsenic Exposure and Metabolism With Type 1 and Type 2 Diabetes in Youth: The SEARCH Case-Control Study

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Carolina Digital Repository