Molecular Characterization of the Lipid Genome-Wide Association Study Signal on Chromosome 18q11.2 Implicates HNF4A-Mediated Regulation of the TMEM241 GeneHighlights

Aguilar-Salinas, Carlos A.; Alvarez, Marcus; Arellano-Campos, Olimpia; Bhagat, Yash; Cruz-Bautista, Ivette; Gonzalez, Luis; Ko, Arthur; Laakso, Markku; Miao, Zong; Mohlke, Karen L.; Muñoz-Hernández, Linda L.; Nikkola, Elina; Ordóñez-Sánchez, Maria-Luisa; Pajukanta, Päivi; Rodriguez-Guillen, Rosario; Rodríguez, Alejandra; Tusie-Luna, Teresa

Molecular Characterization of the Lipid Genome-Wide Association Study Signal on Chromosome 18q11.2 Implicates HNF4A-Mediated Regulation of the TMEM241 GeneHighlights

Authors: Carlos A. Aguilar-Salinas
Marcus Alvarez
Olimpia Arellano-Campos
Yash Bhagat
Ivette Cruz-Bautista
Luis Gonzalez
Arthur Ko
Markku Laakso
Zong Miao
Karen L. Mohlke
Linda L. Muñoz-Hernández
Elina Nikkola
Maria-Luisa Ordóñez-Sánchez
Päivi Pajukanta
Rosario Rodriguez-Guillen
Alejandra Rodríguez
Teresa Tusie-Luna
Publication date: 1 January 2016
Publisher
Doi

Abstract

We recently identified a locus on chromosome 18q11.2 for high serum triglycerides (TGs) in Mexicans. We hypothesize that the lead GWAS single nucleotide polymorphism (SNP) rs9949617, or its linkage disequilibrium (LD) proxies, regulate one of the 5 genes in the TG-associated region

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