922-927The non-steroidal antiinflammatory drug diclofenac
sodium exhibited remarkable inhibitory action against both drug sensitive and
drug resistant clinical isolates of Mycobacterium tuberculosis, as well as
other mycobacteria. This agent was tested in vitro against 45 different strains
of mycobacteria, most of which were inhibited by the drug at 10-25 μg/ml
concentration. When tested in vivo, diclofenac, injected at 10 mg/kg body
weight of a Swiss strain of white mice, could significantly
protect them when challenged with a 50 median lethal dose of M. tuberculosis
H37 Rv102. According to Chisquare test, the in vivo data were
highly significant (P0.01)