Effect of <i>Aegle marmelos </i>Correa. (Bael) fruit extract on tissue antioxidants in <span style="font-size:14.0pt;line-height:115%;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";color:#333333;mso-ansi-language:EN-IN; mso-fareast-language:EN-IN;mso-bidi-language:HI" lang="EN-IN">streptozotocin <span style="font-size:14.0pt;line-height:115%;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";color:#1B1B1B;mso-ansi-language:EN-IN; mso-fareast-language:EN-IN;mso-bidi-language:HI" lang="EN-IN">diabetic rats</span></span>
Abstract
1285-1288A study was undertaken to evaluate the anti -lipid peroxidative activity of an aqueous extract of A. marmelos fruits (AMFEt) in streptozotocin diabetic rats in heart and pancreas. Oral administration of AMFEt for 30 days (125 and 250 mg Kg-1 body weight twice daily) produced a significant decrease in the elevated levels of peroxidation products, viz.thiobarbituric acid reactive substances and hydroperoxides in the tissues of diabetic rats. The depressed activities of <span style="font-size:14.0pt;line-height:115%;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";color:#4B4B4B;mso-ansi-language:EN-IN; mso-fareast-language:EN-IN;mso-bidi-language:HI" lang="EN-IN">s<span style="font-size:14.0pt;line-height:115%;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";color:#1B1B1B;mso-ansi-language:EN-IN; mso-fareast-language:EN-IN;mso-bidi-language:HI" lang="EN-IN">up<span style="font-size:14.0pt;line-height:115%;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";color:#4B4B4B;mso-ansi-language:EN-IN; mso-fareast-language:EN-IN;mso-bidi-language:HI" lang="EN-IN">eroxide <span style="font-size:14.0pt;line-height:115%;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";color:#333333;mso-ansi-language:EN-IN; mso-fareast-language:EN-IN;mso-bidi-language:HI" lang="EN-IN">dismutase, catalase and glutathione peroxidase and <span style="font-size:14.0pt; line-height:115%;font-family:"Times New Roman";mso-fareast-font-family:"Times New Roman"; color:#1B1B1B;mso-ansi-language:EN-IN;mso-fareast-language:EN-IN;mso-bidi-language: HI" lang="EN-IN">lowered <span style="font-size:14.0pt;line-height:115%; font-family:"Times New Roman";mso-fareast-font-family:"Times New Roman"; color:#4B4B4B;mso-ansi-language:EN-IN;mso-fareast-language:EN-IN;mso-bidi-language: HI" lang="EN-IN">g<span style="font-size:14.0pt;line-height:115%; font-family:"Times New Roman";mso-fareast-font-family:"Times New Roman"; color:#1B1B1B;mso-ansi-language:EN-IN;mso-fareast-language:EN-IN;mso-bidi-language: HI" lang="EN-IN">lutathion<span style="font-size:14.0pt;line-height:115%; font-family:"Times New Roman";mso-fareast-font-family:"Times New Roman"; color:#4B4B4B;mso-ansi-language:EN-IN;mso-fareast-language:EN-IN;mso-bidi-language: HI" lang="EN-IN">e <span style="font-size:14.0pt;line-height:115%; font-family:"Times New Roman";mso-fareast-font-family:"Times New Roman"; color:#333333;mso-ansi-language:EN-IN;mso-fareast-language:EN-IN;mso-bidi-language: HI" lang="EN-IN">content <span style="font-size:14.0pt;line-height:115%; font-family:"Times New Roman";mso-fareast-font-family:"Times New Roman"; color:#1B1B1B;mso-ansi-language:EN-IN;mso-fareast-language:EN-IN;mso-bidi-language: HI" lang="EN-IN">in th<span style="font-size:14.0pt;line-height:115%; font-family:"Times New Roman";mso-fareast-font-family:"Times New Roman"; color:#4B4B4B;mso-ansi-language:EN-IN;mso-fareast-language:EN-IN;mso-bidi-language: HI" lang="EN-IN">e <span style="font-size:14.0pt;line-height:115%; font-family:"Times New Roman";mso-fareast-font-family:"Times New Roman"; color:#1B1B1B;mso-ansi-language:EN-IN;mso-fareast-language:EN-IN;mso-bidi-language: HI" lang="EN-IN">heart <span style="font-size:14.0pt;line-height:115%; font-family:"Times New Roman";mso-fareast-font-family:"Times New Roman"; color:#4B4B4B;mso-ansi-language:EN-IN;mso-fareast-language:EN-IN;mso-bidi-language: HI" lang="EN-IN">a<span style="font-size:14.0pt;line-height:115%; font-family:"Times New Roman";mso-fareast-font-family:"Times New Roman"; color:#1B1B1B;mso-ansi-language:EN-IN;mso-fareast-language:EN-IN;mso-bidi-language: HI" lang="EN-IN">nd pancr<span style="font-size:14.0pt;line-height:115%; font-family:"Times New Roman";mso-fareast-font-family:"Times New Roman"; color:#4B4B4B;mso-ansi-language:EN-IN;mso-fareast-language:EN-IN;mso-bidi-language: HI" lang="EN-IN">eas <span style="font-size:14.0pt;line-height:115%; font-family:"Times New Roman";mso-fareast-font-family:"Times New Roman"; color:#333333;mso-ansi-language:EN-IN;mso-fareast-language:EN-IN;mso-bidi-language: HI" lang="EN-IN">of diabetic <span style="font-size:14.0pt;line-height: 115%;font-family:"Times New Roman";mso-fareast-font-family:"Times New Roman"; color:#1B1B1B;mso-ansi-language:EN-IN;mso-fareast-language:EN-IN;mso-bidi-language: HI" lang="EN-IN">r<span style="font-size:14.0pt;line-height:115%; font-family:"Times New Roman";mso-fareast-font-family:"Times New Roman"; color:#4B4B4B;mso-ansi-language:EN-IN;mso-fareast-language:EN-IN;mso-bidi-language: HI" lang="EN-IN">ats <span style="font-size:14.0pt;line-height:115%; font-family:"Times New Roman";mso-fareast-font-family:"Times New Roman"; color:#333333;mso-ansi-language:EN-IN;mso-fareast-language:EN-IN;mso-bidi-language: HI" lang="EN-IN">were found <span style="font-size:14.0pt;line-height: 115%;font-family:"Times New Roman";mso-fareast-font-family:"Times New Roman"; color:#1B1B1B;mso-ansi-language:EN-IN;mso-fareast-language:EN-IN;mso-bidi-language: HI" lang="EN-IN">t<span style="font-size:14.0pt;line-height:115%; font-family:"Times New Roman";mso-fareast-font-family:"Times New Roman"; color:#4B4B4B;mso-ansi-language:EN-IN;mso-fareast-language:EN-IN;mso-bidi-language: HI" lang="EN-IN">o <span style="font-size:14.0pt;line-height:115%; font-family:"Times New Roman";mso-fareast-font-family:"Times New Roman"; color:#333333;mso-ansi-language:EN-IN;mso-fareast-language:EN-IN;mso-bidi-language: HI" lang="EN-IN">increase <span style="font-size:14.0pt;line-height:115%; font-family:"Times New Roman";mso-fareast-font-family:"Times New Roman"; color:#4B4B4B;mso-ansi-language:EN-IN;mso-fareast-language:EN-IN;mso-bidi-language: HI" lang="EN-IN">on <span style="font-size:14.0pt;line-height:115%; font-family:"Times New Roman";mso-fareast-font-family:"Times New Roman"; color:#1B1B1B;mso-ansi-language:EN-IN;mso-fareast-language:EN-IN;mso-bidi-language: HI" lang="EN-IN">tr<span style="font-size:14.0pt;line-height:115%; font-family:"Times New Roman";mso-fareast-font-family:"Times New Roman"; color:#4B4B4B;mso-ansi-language:EN-IN;mso-fareast-language:EN-IN;mso-bidi-language: HI" lang="EN-IN">eatmen<span style="font-size:14.0pt;line-height:115%; font-family:"Times New Roman";mso-fareast-font-family:"Times New Roman"; color:#1B1B1B;mso-ansi-language:EN-IN;mso-fareast-language:EN-IN;mso-bidi-language: HI" lang="EN-IN">t <span style="font-size:14.0pt;line-height:115%; font-family:"Times New Roman";mso-fareast-font-family:"Times New Roman"; color:#333333;mso-ansi-language:EN-IN;mso-fareast-language:EN-IN;mso-bidi-language: HI" lang="EN-IN">with AMFEt. AMFEt at <span style="font-size:14.0pt; line-height:115%;font-family:"Times New Roman";mso-fareast-font-family:"Times New Roman"; color:#4B4B4B;mso-ansi-language:EN-IN;mso-fareast-language:EN-IN;mso-bidi-language: HI" lang="EN-IN">a <span style="font-size:14.0pt;line-height:115%; font-family:"Times New Roman";mso-fareast-font-family:"Times New Roman"; color:#333333;mso-ansi-language:EN-IN;mso-fareast-language:EN-IN;mso-bidi-language: HI" lang="EN-IN">dose of 250 <span style="font-size:14.0pt;line-height: 115%;font-family:"Times New Roman";mso-fareast-font-family:"Times New Roman"; color:#1B1B1B;mso-ansi-language:EN-IN;mso-fareast-language:EN-IN;mso-bidi-language: HI" lang="EN-IN">mg <span style="font-size:14.0pt;line-height:115%; font-family:"Times New Roman";mso-fareast-font-family:"Times New Roman"; color:#333333;mso-ansi-language:EN-IN;mso-fareast-language:EN-IN;mso-bidi-language: HI" lang="EN-IN">kg<span style="font-size:14.0pt;line-height:115%; font-family:"Times New Roman";mso-fareast-font-family:"Times New Roman"; color:#626262;mso-ansi-language:EN-IN;mso-fareast-language:EN-IN;mso-bidi-language: HI" lang="EN-IN">-1<span style="font-size:14.0pt;line-height:115%; font-family:"Times New Roman";mso-fareast-font-family:"Times New Roman"; color:#626262;mso-ansi-language:EN-IN;mso-fareast-language:EN-IN;mso-bidi-language: HI" lang="EN-IN"> <span style="font-size:14.0pt;line-height:115%; font-family:"Times New Roman";mso-fareast-font-family:"Times New Roman"; color:#333333;mso-ansi-language:EN-IN;mso-fareast-language:EN-IN;mso-bidi-language: HI" lang="EN-IN">was more <span style="font-size:14.0pt;line-height:115%; font-family:"Times New Roman";mso-fareast-font-family:"Times New Roman"; color:#4B4B4B;mso-ansi-language:EN-IN;mso-fareast-language:EN-IN;mso-bidi-language: HI" lang="EN-IN">e<span style="font-size:14.0pt;line-height:115%; font-family:"Times New Roman";mso-fareast-font-family:"Times New Roman"; color:#1B1B1B;mso-ansi-language:EN-IN;mso-fareast-language:EN-IN;mso-bidi-language: HI" lang="EN-IN">ffe<span style="font-size:14.0pt;line-height:115%; font-family:"Times New Roman";mso-fareast-font-family:"Times New Roman"; color:#4B4B4B;mso-ansi-language:EN-IN;mso-fareast-language:EN-IN;mso-bidi-language: HI" lang="EN-IN">c<span style="font-size:14.0pt;line-height:115%; font-family:"Times New Roman";mso-fareast-font-family:"Times New Roman"; color:#1B1B1B;mso-ansi-language:EN-IN;mso-fareast-language:EN-IN;mso-bidi-language: HI" lang="EN-IN">ti<span style="font-size:14.0pt;line-height:115%; font-family:"Times New Roman";mso-fareast-font-family:"Times New Roman"; color:#4B4B4B;mso-ansi-language:EN-IN;mso-fareast-language:EN-IN;mso-bidi-language: HI" lang="EN-IN">ve <span style="font-size:14.0pt;line-height:115%; font-family:"Times New Roman";mso-fareast-font-family:"Times New Roman"; color:#333333;mso-ansi-language:EN-IN;mso-fareast-language:EN-IN;mso-bidi-language: HI" lang="EN-IN">than glibenclamide <span style="font-size:14.0pt; line-height:115%;font-family:"Times New Roman";mso-fareast-font-family:"Times New Roman"; color:#4B4B4B;mso-ansi-language:EN-IN;mso-fareast-language:EN-IN;mso-bidi-language: HI" lang="EN-IN">(300μ<span style="font-size:14.0pt;line-height:115%; font-family:"Times New Roman";mso-fareast-font-family:HiddenHorzOCR;color:#4B4B4B; mso-ansi-language:EN-IN;mso-fareast-language:EN-IN;mso-bidi-language:HI" lang="EN-IN">g <span style="font-size:14.0pt;line-height:115%;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";color:#333333;mso-ansi-language:EN-IN; mso-fareast-language:EN-IN;mso-bidi-language:HI" lang="EN-IN">kg<span style="font-size:14.0pt;line-height:115%;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";color:#626262;mso-ansi-language:EN-IN; mso-fareast-language:EN-IN;mso-bidi-language:HI" lang="EN-IN">-<span style="font-size:14.0pt;line-height:115%;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";color:#1B1B1B;mso-ansi-language:EN-IN; mso-fareast-language:EN-IN;mso-bidi-language:HI" lang="EN-IN">l<span style="font-size:14.0pt;line-height:115%;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";color:#4B4B4B;mso-ansi-language:EN-IN; mso-fareast-language:EN-IN;mso-bidi-language:HI" lang="EN-IN">) and <span style="font-size:14.0pt;line-height:115%;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";color:#333333;mso-ansi-language:EN-IN; mso-fareast-language:EN-IN;mso-bidi-language:HI" lang="EN-IN">both rev<span style="font-size:14.0pt;line-height:115%;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";color:#626262;mso-ansi-language:EN-IN; mso-fareast-language:EN-IN;mso-bidi-language:HI" lang="EN-IN">e<span style="font-size:14.0pt;line-height:115%;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";color:#333333;mso-ansi-language:EN-IN; mso-fareast-language:EN-IN;mso-bidi-language:HI" lang="EN-IN">r<span style="font-size:14.0pt;line-height:115%;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";color:#626262;mso-ansi-language:EN-IN; mso-fareast-language:EN-IN;mso-bidi-language:HI" lang="EN-IN">se<span style="font-size:14.0pt;line-height:115%;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";color:#333333;mso-ansi-language:EN-IN; mso-fareast-language:EN-IN;mso-bidi-language:HI" lang="EN-IN">d <span style="font-size:14.0pt;line-height:115%;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";color:#4B4B4B;mso-ansi-language:EN-IN; mso-fareast-language:EN-IN;mso-bidi-language:HI" lang="EN-IN">a<span style="font-size:14.0pt;line-height:115%;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";color:#1B1B1B;mso-ansi-language:EN-IN; mso-fareast-language:EN-IN;mso-bidi-language:HI" lang="EN-IN">ll th<span style="font-size:14.0pt;line-height:115%;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";color:#626262;mso-ansi-language:EN-IN; mso-fareast-language:EN-IN;mso-bidi-language:HI" lang="EN-IN">e va<span style="font-size:14.0pt;line-height:115%;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";color:#333333;mso-ansi-language:EN-IN; mso-fareast-language:EN-IN;mso-bidi-language:HI" lang="EN-IN">lue<span style="font-size:14.0pt;line-height:115%;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";color:#626262;mso-ansi-language:EN-IN; mso-fareast-language:EN-IN;mso-bidi-language:HI" lang="EN-IN">s s<span style="font-size:14.0pt;line-height:115%;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";color:#333333;mso-ansi-language:EN-IN; mso-fareast-language:EN-IN;mso-bidi-language:HI" lang="EN-IN">ignificantly. Thus AMFEt <span style="font-size:14.0pt;line-height:115%;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";color:#4B4B4B;mso-ansi-language:EN-IN; mso-fareast-language:EN-IN;mso-bidi-language:HI" lang="EN-IN">ex<span style="font-size:14.0pt;line-height:115%;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";color:#1B1B1B;mso-ansi-language:EN-IN; mso-fareast-language:EN-IN;mso-bidi-language:HI" lang="EN-IN">hibit<span style="font-size:14.0pt;line-height:115%;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";color:#4B4B4B;mso-ansi-language:EN-IN; mso-fareast-language:EN-IN;mso-bidi-language:HI" lang="EN-IN">s an<span style="font-size:14.0pt;line-height:115%;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";color:#1B1B1B;mso-ansi-language:EN-IN; mso-fareast-language:EN-IN;mso-bidi-language:HI" lang="EN-IN">ti-<span style="font-size:14.0pt;line-height:115%;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";color:#4B4B4B;mso-ansi-language:EN-IN; mso-fareast-language:EN-IN;mso-bidi-language:HI" lang="EN-IN">oxidative activity <span style="font-size:14.0pt;line-height:115%;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";color:#333333;mso-ansi-language:EN-IN; mso-fareast-language:EN-IN;mso-bidi-language:HI" lang="EN-IN">in streptozotocin diabetic rats.</spanSimilar works
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