ABSTRACT
Chitosan-alginate membrane diffusion behavior has been investigated for its application in drugs delivery
system. Ketoprofen diffusion behavior assay were performed at 37 and 42°C to membrane thickness (h) and donor cell concentration of ketoprofen variations (A). The results showed that e9uilibrium concentrations (Cs)of ketoprofen equation was 27.0087 + 0.09067T - 1.7499h + 0.1030A + 0.0161h - 0.0022A2 + 0.0040Th - 0.0018TA + 0.0095hA. The value of Cswas closer to the expected therapy concentration at 50 and 75 mg/L with thin membrane (10-34 11m).Based on Higuchi equation, the model forJ and D were J = 11.0849- 0.2713T- 0.3132h- 0.7461Cs-0.0096A - 0.0001h2- 0.0131C/ + 0.0002A2 + 0.0084Th + 0.0275TCs- 0.0018TA - 0.0059hCs + 0.0021hA + 0.0037C,A with ~ = 97.9% and D = -12.5000 + 0.2266T + 0.1313h + 0.1538Cs+ 0.1200A - 0.0009h2+ 0.0240 C/- 0.0009A2+ 0.0015Th- 0.0150 TCs- 0.0011TA- 0.0096hCs+ 0.0004hA+ 0.0039C,Awith ~ = 98.7%, respectively. The two dimensional contour maps of J versus A and h, both at 37 and 42°C, showed an increasing of J value as A, h, or T increased.
Keywords: ketoprofen, chitosan-alginate, diffusio
