STRUCTURAL REDETERMINATION OF NEW ERYTHROMYCIN DERIVATIVE : 2\u27,4"-O-DIMETHYLERYTHROMYCIN A USING 2D(I3C 1H)-NMR SPECTROMETRIC ANALYSIS (DETERMINASI KEMBALI STRUKTUR TURUNAN ERITROMISIN BARU: 2 \u27,4"-O-DIMETILERITROMISIN A

Abstract

ABSTRACT Redetermination of the chemical structure of the sample E-1 has been carried out using 2D(\u27 3C-\u27H) NMR spectrometric approach. The appearance of cross-peaks at OHSc (3.2850.1) and (3.3350.0) strongly suggested the present of two methoxy groups at C-2\u27 of the desosarnine and C-4" of the cladinose respectively. This spectrometric analysis confirmed that the E-1 chemical structure is 2\u27.4"-O-Dimethylerythromycin A. Key-words : 2D(13C-\u27H) NMR. spectrometric approach