Kadar Malondialdehid Plasma dan Hemoglobin Darah Setelah Pemberian Vitamin C pada Manula di Daerah Dataran Tinggi dan Dataran Rendah: Plasma Malondialdehid Concentrations and Blood Hemoglobin after the Administration of

Abstract

The increase of free radicals occurred in the elderly, resulting in the imbalance between free radicals and antioxidants. Antioxidants such as glutathion, vitamin C, and vitamin E were potential substances for the treatment of the elderly in connecting oxidative stress. Vitamin C is a water soluble compound that is considered as an chain-breaking antioxidant. lion absorption, as Fe is also enhanced by simultaneous ingestion of the vitamin C, but ascorbic acid serves no spesific function in hematopoesis. Vitamin E regeneration takes place spontaneously in response to ascorbic acid therapy. The problem of this study was whether the administration vitamin C could decrease plasma malondialdehyde concentration and increase hemoglobin concentration with two elderly groups living in the highlands and the lowland. The aim of this study was to assess the decrease of plasma malondialdehyde and increase of blood hemoglobin concentration after administration of vitamin C in the highlands and the lowland elderly groups. Experimental study with the same subject had been done. The subjects of this study were elderly groups, aged 60-80 years, healthy and able to do daily physical activities The elderly were divided into 2 groups : the highlands elderly who consisted of 24 elders (KDT) and the lowland elderly who consisted of 19 elderly (KDR). Blood samples were taken two times i.e before (sample I) and after (sample II) vitamin C administration for thirty consecutive days. Plasma malondialdehyde concentration had been measured by Yagi method. Plasma vitamin C concentration and blood hemoglobin were analysed according to colorimetris methods (Tiezt, 1986). The results showed that the average concentrations of MDA of KDR in sample I was 2,86 ± 0,69 nmol/ml, in sample II was 2,07±0,39 nmol /ml. The average concentrations of MDA of KDT in sample I was 3,50 ± 0,57 nmol /m1 and sample II 2,69 ± 0,49 nmol/ml. The averag