In this paper, we report that in pulmonary aspergillosis patient who had history of resection of the stomach, the blood concentrations of itraconazole（ITCZ）and its active metabolite, hydroxy-ITCZ（OHITCZ） after taking oral solid formulation of ITCZ were remarkably low, whereas their blood concentrations significantly increased after switching from the solid formulation to the solution formulation.During administration of the ITCZ tablets（200 mg/day）, trough blood concentration of ITCZ and OH-ITCZ were 15 ng/mL and 18 ng/mL, respectively. On the other hand, when it was switched from the tablet to the oral solution（200 mg/day as ITCZ）, blood concentrations of ITCZ and OH-ITCZ increased to 1056 ng/mL and 1492 ng/mL, respectively. It was considered that the absorption of ITCZ tablets declined because the gastric acid secretion ability of the patients was decreased by gastrectomy.研究ノー
