Two novel polychiral furanopyrans from <em>Orthosiphon diffusus</em> (Benth.)

Abstract

855-861Chemical investigation on Orthosiphon diffusus has resulted in the isolation of two new polychiral furanopyrans, orthodiffenes AM-1 and AM-2 which have been thoroughly characterized by detailed spectroscopic studies including IR, NMR (1D and 2D) and FABMS spectra. The in vitro cytotoxic activity of these two compounds has been tested against U-937 and HeLa cells using camptothecin and etoposide as the positive controls. Both the metabolites show modest activity against HeLa cells with IC50 values of 26.98 &micro;g/mL and 21.18 &micro;g/mL, respectively