1256-1264A series of diazotized sulphonamides have undergone azo coupling with the newly synthesized Schiff base ligand (E)-N-((2-chloroquinolin-3-yl)methylene)-4-phenylthiazol-2-amine 3a and (E)-4-(4-chlorophenyl)-N-((2-chloroquinolin-3-yl)methylene)-thiazol-2-amine 3b to give quinoline-thiazole based azo compounds. The solvent effect of the resulting compounds has been studied with different solvents. The structural confirmation of all the synthesized congeners has been carried out by different spectral techniques such as elemental analysis, 1H NMR, FT-IR, UV-Vis and LC-MS. The results of in vitro cytotoxic activity of the synthesized compounds has revealed that the compounds N-(4-(((Z)-(2-chloroquinolin-3-yl)(4-phenylthiazol-2-ylimino)methyl)diazenyl)phenylsulfonyl)acetamide 5b, 4-(((Z)-(2-chloroquinolin-3-yl)(4-phenylthiazol-2-ylimino) methyl)diazenyl)-benzenesulfonic acid 5d and 4-(((Z)-(4-(4-chlorophenyl) thiazol-2-ylimino) (2-chloroquinolin-3yl)methyl)diazenyl) benzene-sulfonic acid 5h show excellent cytotoxic action against MCF 7 (human breast cancer cell line) and K562 (CML cell line)
