<span style="font-size:10.0pt;font-family: "Times New Roman";mso-fareast-font-family:"Times New Roman";mso-bidi-font-family: Mangal;mso-ansi-language:EN-US;mso-fareast-language:EN-US;mso-bidi-language: HI;mso-bidi-font-weight:bold" lang="EN-US">Design and synthesis of new <i><span style="font-size:10.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-bidi-font-family:Mangal;mso-ansi-language:EN-US; mso-fareast-language:EN-US;mso-bidi-language:HI" lang="EN-US">N</span></i><span style="font-size:10.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-bidi-font-family:Mangal;mso-ansi-language:EN-US; mso-fareast-language:EN-US;mso-bidi-language:HI" lang="EN-US">'-substituted- 2-methylquinoline-3-carbohydrazides with antioxidant and antimicrobial activity</span></span>

Abstract

930-935Ten new N'-substituted-2-methylquinoline-3-carbohydrazide scaffolds have been synthesized, characterized by their physical and spectral data (IR, 1H NMR, and MS) and screened for in vitro antimicrobial and antioxidant activities. Results clearly reveal that all the synthesized compounds possess in vitro <span style="mso-bidi-font-weight: bold">antioxidant activity at the tested dose as compared to the standard drug, ascorbic acid. From the results, it can be assumed that the presence of an electron donating group on the aromatic ring is an important requirement for the antioxidant activity of the synthesized compounds, <b style="mso-bidi-font-weight: normal">5a-j. The synthesized compounds have also been screened for antibacterial and antifungal activity against three different strains of Gram-positive (<i style="mso-bidi-font-style: normal">Bacillus subtilis, S. pyogens<span style="mso-bidi-font-style: italic">, and Staphylococcus aureus) and three strains of Gram-negative bacteria (<i style="mso-bidi-font-style: normal">Escherichia coli, Enterobactor aerogens and<span style="mso-bidi-font-style: italic"> Klebsiella pneumoniae) and two fungal strains (Candida albicans and <i style="mso-bidi-font-style: normal">Fusarium oxysporium). Some of the compounds are found to be active against all the tested organisms, but are equipotent and less active as compared to the standard drug streptomycin. Compounds 5b and 5j exhibit almost equipotent activity compared with the standard drug Itraconazol against fungal strain <i style="mso-bidi-font-style: normal">Fusarium oxysporium and another compound 5f which is <span style="mso-bidi-font-weight: bold">active against Candida albicans. </span