<span style="color:black;mso-bidi-language:HI">One pot facile synthesis of 5-alkyl-1,2-dihydro-spiro[4<i>H</i>-3, 1-benzoxazine<span style="color:#030303;mso-bidi-language:HI">- <span style="color:black;mso-bidi-language:HI">2<span style="color:#030303; mso-bidi-language:HI">,<span style="color:black;mso-bidi-language:HI">3'[3<i>H</i>]indol]-4,2'-diones under microwave irradiation </span></span></span></span></span>

Abstract

1504-1510A fa<span style="color:#030303; mso-bidi-language:HI">cile sy<span style="color:black; mso-bidi-language:HI">nth<span style="color:#030303;mso-bidi-language: HI">esis of some n<span style="color:#030303; mso-bidi-language:HI">ove<span style="color:black;mso-bidi-language: HI">l 5-al<span style="color:#030303; mso-bidi-language:HI">kyl-1,2-d<span style="color:black; mso-bidi-language:HI">ih<span style="color:#030303;mso-bidi-language: HI">ydro-s<span style="color:black; mso-bidi-language:HI">pir<span style="color:#030303;mso-bidi-language: HI">o[4H-3, 1-<span style="color:#030303; mso-bidi-language:HI">benzoxa<span style="color:black; mso-bidi-language:HI">zin<span style="color:#030303;mso-bidi-language: HI">e-2,<span style="color:black; mso-bidi-language:HI">3<span style="color:#030303;mso-bidi-language: HI">'[3H]ind<span style="color:#030303; mso-bidi-language:HI">ol]-4<span style="color:#303030; mso-bidi-language:HI">,<span style="color:#030303;mso-bidi-language: HI">2'-dio<span style="color:black; mso-bidi-language:HI">ne<span style="color:#030303;mso-bidi-language: HI">s, in <span style="color:#030303; mso-bidi-language:HI">hig<span style="color:black; mso-bidi-language:HI">h <span style="color:#030303;mso-bidi-language: HI">yiel<span style="color:black; mso-bidi-language:HI">d<span style="color:#030303;mso-bidi-language: HI">s, has bee<span style="color: black;mso-bidi-language:HI">n <span style="color:#030303;mso-bidi-language: HI">carried o<span style="color:black; mso-bidi-language:HI">u<span style="color:#030303;mso-bidi-language: HI">t cl<span style="color:#030303; mso-bidi-language:HI">assica<span style="color:black;mso-bidi-language: HI">lly as well <span style="color:#030303; mso-bidi-language:HI">as <span style="color:black;mso-bidi-language: HI">under m<span style="color:#030303; mso-bidi-language:HI">icrowave ir<span style="color:#030303; mso-bidi-language:HI">radiat<span style="color:black; mso-bidi-language:HI">i<span style="color:#030303;mso-bidi-language: HI">on in so<span style="color:black; mso-bidi-language:HI">l<span style="color:#030303;mso-bidi-language: HI">vent fr<span style="color:black; mso-bidi-language:HI">e<span style="color:#030303;mso-bidi-language: HI">e conditio<span style="color:black; mso-bidi-language:HI">n<span style="color:#030303;mso-bidi-language: HI">s. Microwave ir<span style="color:#030303; mso-bidi-language:HI">radiation offer<span style="color:#030303; mso-bidi-language:HI">s tre<span style="color:black;mso-bidi-language: HI">men<span style="color:#030303; mso-bidi-language:HI">dous adva<span style="color: black;mso-bidi-language:HI">nt<span style="color:#030303;mso-bidi-language: HI">ages in t<span style="color:black; mso-bidi-language:HI">h<span style="color:#030303;mso-bidi-language: HI">e form of s<span style="color:black; mso-bidi-language:HI">h<span style="color:#030303;mso-bidi-language: HI">ort<span style="color:black; mso-bidi-language:HI">er <span style="color:#030303;mso-bidi-language: HI">reactio<span style="color:black; mso-bidi-language:HI">n t<span style="color:#030303;mso-bidi-language: HI">ime<span style="color:#303030; mso-bidi-language:HI">, <span style="color:#030303;mso-bidi-language: HI">opera<span style="color:black; mso-bidi-language:HI">ti<span style="color:#030303;mso-bidi-language: HI">onal s<span style="color:black; mso-bidi-language:HI">im<span style="color:#030303;mso-bidi-language: HI">plic<span style="color:black; mso-bidi-language:HI">it<span style="color:#030303;mso-bidi-language: HI">y, cl<span style="color:#030303; mso-bidi-language:HI">eane<span style="color:black; mso-bidi-language:HI">r <span style="color:#030303;mso-bidi-language: HI">reactio<span style="color:black; mso-bidi-language:HI">n<span style="color:#030303;mso-bidi-language: HI">, easy work-up a<span style="color:black; mso-bidi-language:HI">nd bett<span style="color:#030303;mso-bidi-language: HI">er yields <span style="color:black; mso-bidi-language:HI">as c<span style="color:#030303;mso-bidi-language: HI">ompared <span style="color:black; mso-bidi-language:HI">to th<span style="color:#030303;mso-bidi-language: HI">e classica<span style="color:black; mso-bidi-language:HI">l me<span style="color:#030303;mso-bidi-language: HI">tho<span style="color:black; mso-bidi-language:HI">d. B<span style="color:#030303;mso-bidi-language: HI">esides this<span style="color:black; mso-bidi-language:HI">, som<span style="color:#030303;mso-bidi-language: HI">e nove<span style="color:black; mso-bidi-language:HI">l 6-alk<span style="color:#030303;mso-bidi-language: HI">yla<span style="color:black; mso-bidi-language:HI">nthr<span style="color:#030303;mso-bidi-language: HI">anilic ac<span style="color:black; mso-bidi-language:HI">ids r<span style="color:#030303;mso-bidi-language: HI">equired fo<span style="color:black; mso-bidi-language:HI">r th<span style="color:#030303;mso-bidi-language: HI">e synthes<span style="color:black; mso-bidi-language:HI">is of new spiro compounds have also been synthesized. The importance of alkyl substituent at C-6 position in anthranilic acid has been recognized again in such a cyclocondensation reaction, even when it is carried out under microwave irradiation. This is also supported by molecular modeling. </span