512-519Phospholipid remodeling and eicosanoid
synthesis are central to lipid-based inflammatory reactions. Studies have
revealed that membrane phospholipid remodeling by fatty acids through
deacylation/reacylation reactions increases the risk of colorectal cancers
(CRC) by allowing the cells to produce excess inflammatory eicosanoids, such as
prostaglandins, thromboxanes and leukotrienes. Over the years, efforts have
been made to understand the lipid remodeling pathways and to design anti-cancer
drugs targeting the enzymes of eicosanoid biosynthesis. Here, we discuss the
recent progress in phospholipid remodeling and eicosanoid biosynthesis in CRC