Insulin secreting and α-glucosidase inhibitory activity of hexane extract of <i style="mso-bidi-font-style:normal">Annona squamosa</i> Linn. in streptozotocin (STZ) induced diabetic rats

Abstract

623-629The hexane extract of A. squamosa<span style="mso-bidi-font-style: italic"> <span style="mso-bidi-font-weight:bold; mso-bidi-font-style:italic" lang="EN-GB">(ASHE) in 100 and 400 mg/kg body weight dose raised the insulin level when compared with Glimepiride (1 mg/kg) and also inhibited α-glucosidase activity when compared with Acarbose (10 mg/kg) in streptozotocin induced diabetic rats. <span style="mso-bidi-font-weight: bold">The ASHE significantly reduced peak blood glucose (Gp30) and area under curve (AUC) in diabetic rats in oral glucose (OGTT) and oral sucrose (OSTT) tolerance test, but there was more reduction of Gp30 value than AUC in OSTT. Thus, it can be suggested that the ASHE, has hypoglycemic role at 2 levels, i.e. it acts as secretagogue and also inhibits the intestinal enzymes, responsible for glucose metabolism. </span