129-133The objective of the present study was to
investigate the protective effect of ethanolic extract of <i style="mso-bidi-font-style:
normal">Psidium guajava L. leaves against doxorubicin-induced
nephrotoxicity in rats. Animals treated with doxorubicin (8mg/kg, i.p) once
daily for
2 days significantly (P<0.05) increased Serum Urea, BUN, creatinine, total protein,
LPO and significantly (P<0.05)
decreased CAT, SOD, GSH levels as compared to vehicle treated rats. Treatment
with P. guajava (100 & 300 mg/kg,
p.o) showed significant (P<0.05)
decrease in Serum Urea, BUN, creatinine, total protein, LPO and significant (P<0.05) increase in CAT, SOD, GSH
levels as compared to doxorubicin treated group. Histopathological examinations
of kidney tissue showed that doxorubicin changed the renal architecture
significantly which was less evident in P.
guajava
(100 mg/kg & 300 mg/kg) pre-treated rats. Results suggest that P. guajava extract has the potential to
ameliorate doxorubicin induced nephrotoxicity and might serve as a novel
combination agent with doxorubicin to limit renal damage