88-90Angiogenesis or the generation of new
blood vessel, is an important factor in the growth of a solid tumor. Hence, it becomes
a necessary parameter of any kind of therapeutic study. Glutamine is an essential
nutrient of tumor tissue and glutamine related therapy involves clearance of
circulatory glutamine by glutaminase. Therefore, using different murine solid tumor
models, the present study was undertaken to find out whether the S-180 cell
glutaminase has any effect on angiogenesis of solid tumor, or not. Result
indicates that the purified S-180 cell glutaminase reduces tumor volume and restrict
the generation of neo blood vessels. Therefore, it can be concluded that this enzyme
may be an effective device
against the cancer metastasis