N-Phthaloyl gamma-aminobutyric acid affects biochemical circadian rhythms in Wistar rats

Abstract

360-364<span style="font-size:14.0pt;mso-bidi-font-size:8.0pt; line-height:115%;font-family:" arial","sans-serif";mso-fareast-font-family:"times="" new="" roman";="" color:black;mso-ansi-language:en-us;mso-fareast-language:en-us;mso-bidi-language:="" ar-sa"="">N-Phthaloyl gamma-aminobutyric acid (P-GABA) was administered to Wistar rats and 24 hr rhythms of glucose, cholesterol, total protein and lactic acid levels in blood were studied under semi-natural light dark conditions. P-GABA administration caused desynchronisation of the rhythms; while glucose and lactic acid rhythms were advanced, <span style="font-size:12.0pt; mso-bidi-font-size:6.0pt;line-height:115%;font-family:HiddenHorzOCR;mso-hansi-font-family: Arial;mso-bidi-font-family:HiddenHorzOCR;color:black;mso-ansi-language:EN-US; mso-fareast-language:EN-US;mso-bidi-language:AR-SA">cholesterol <span style="font-size:14.0pt;mso-bidi-font-size:8.0pt;line-height:115%;font-family: " arial","sans-serif";mso-fareast-font-family:"times="" new="" roman";color:black;="" mso-ansi-language:en-us;mso-fareast-language:en-us;mso-bidi-language:ar-sa"="">and total protein rhythms were delayed. Since GABA is being involved in conveying dark information to the clock, exogenous administration of P-GABA may reduce the photic information received by the clock. The results could be explaincd by slightly less than I hr daily delays (or) advances respectively which would bring the peak times to the points 21 days after the start of administration.</span