Synthesis, antimicrobial and antituberculosis activities of <i>N</i>-bridged heterocycles

Abstract

828-833The reactions of 3-[(((α-phenyl/methyl)benzylidene)amino)oxy]methyl/ethyl-4-amino-5-mercapto-4(H)-1,2,4-triazoles 1a-d, with various aliphatic/aromatic acids 2a-d-5a-d, oxalic acid 6a-d, cyanogen bromide 7a-d, carbon disulphide 8a-d, hydrazine hydrate (99%) 9a-d, monochloroacetic acid 10a-d, phenacyl bromide 11a-d, benzoin 12a-d, dimidone 13a-d and chalcone 14a-d are described. The characterisation of the compounds have been done on the basis of elemental analysis and spectral (IR, 1H NMR and mass) data. All the newly synthesised compounds have been screened for antimicrobial activity against B. cirroflagellosus, E. coli, A. niger and R. bataticola. Most of the compounds have also been screened for antituberculosis activity against M. tuberculosis, H37Rv strain. Results of antimicrobial screening revealed that majority of the newly synthesised N-bridged heterocycles exhibit better antimicrobial activity than the standards cotrimoxazole and fluconazole. A few of the compounds exhibit significant antituberculosis activity in comparison with rifampin, the standard used