Synthesis and microbiological action of new dipenicillins and dicephalosporins derived from asparagic acid

Abstract

1467-1471A new synthetic method of some β-lactamic antibiotics containing an asparagic acid residue is described which is based on the acylation of the 6-aminopenicillanic acid (6-APA) and of the 7-aminodesacetoxycephalosporanic acid (7-ADCA), respectively, by acid dichlorides of the N-(o,m,p)-nitrobenzoyl asparagic acids at low temperatures in nonaqueous medium. The structure of the newly synthesized compounds has been elucidated by means of elemental analysis and spectral dam (IR, UV,NMR) and their antibacterial activity has been evaluated