Synthesis and biological study of some new chalcone and pyrazole derivatives

Abstract

807-809Substituted chalcone and pyrazole derivatives have been synthesized by reacting 3-isopropyl-4-methoxybenzaldehyde with various aromatic ketones by using alkali as catalyst to afford (E)-3-(3-Isopropyl-4-methoxyphenyl)-1-aryl-prop-2-en-1-ones 2a-j. Compounds <b style="mso-bidi-font-weight: normal">2a-j on reaction with hydrazine hydrate in the presence of glacial acetic acid give 1-acetyl-3-aryl-5-(3-isopropyl-4-methoxyphenyl)pyrazoles 3a-j. The homogeneity of all the newly synthesized compounds has been checked by TLC. Their IR, 1H NMR, mass spectral data and elemental analysis are in accord with the assigned structure. All the newly synthesized compounds have been screened for antimicrobial activity