Synthesis and reactivity studies of mononuclear zinc hydroxo complex

Abstract

83-87The synthesis of mononuclear zinc hydroxo, Zn(OH)(HB(3-But-5-Pripz) 2 using sterically hindered pyrazolylborate ligand i.e. hydrotris(3-tert-butyl-5-isopropyl-1-pyrazolyl)borate ligand has been described. The structure of 2 is very similar to the active site of the enzyme carbonic anhydrase. The complex 2 is found to stabilize zinc complexes of uracil and its halo derivatives where uracil and its halo derivatives are bound as monodentate ligand via its deprotonated N1. The halogenated uracil complexes have been injected in Dalton's Lymphoma tumour system in mice and it is found that Zn[HB(3-But-5- Pripz)3](5-fluorouracilate) exhibits significant antitumour activity. The complex 2 is a very reactive species and is used as catalyst in ester hydrolysis. The complex 2 is also found to promote the hydrolysis of various esters and the maximum rate of hydrolysis is observed with p-nitrophenylacetate