193-195The activity
of glyoxalase I from the soluble fraction of diabetic rat liver was found to decrease
as compared to the control. Sodium orthovanadate in drinking water and Trigonella
foenum graecum seed powder when administered to these diabetic animals were
found to reverse the activity of glyoxalase [to control values. A combination
of the above two antidiabetic compounds showed a better reversal. Vanadate and Trigonella
seed powder treatment separately to diabetic rats also normalized
hyperglycemia together with glyoxalase I activity. A combination of vanadate
and Trigonella seed powder also restored the other general parameters of
the diabetic animals