<span style="font-size:12.0pt;font-family: "Times New Roman";mso-fareast-font-family:"Times New Roman";mso-ansi-language: EN-GB;mso-fareast-language:EN-US;mso-bidi-language:AR-SA" lang="EN-GB">Synthesis, characterisation and anthelmintic activity of 3-(4-acetyl-5-phenyl-4,5-dihydro-1,3,4-oxadiazol-2-yl)- 2<i style="mso-bidi-font-style: normal">H</i>-chromen-2-one derivatives</span>

Abstract

422-427<span style="mso-ansi-language: EN-US;mso-bidi-font-weight:bold" lang="EN-US">Convectional synthesis of several coumarin-oxadiazole derivatives from starting compounds 2-hydroxy benzaldehyde and diethylmalonate has been accomplished. Successful synthesis of the derivatives has been confirmed by spectral studies i.e. UV, IR, MS and 1H NMR. All successfully synthesized compounds have been screened for in vitro anthelmintic activity by taking adult Indian earthworms Pheretima posthuma. Among all the derivatives 4-chloro derivatives have shown maximum activity when compared with the standard. </span