<span style="font-size:12.0pt;font-family: "Times New Roman";mso-fareast-font-family:"Times New Roman";mso-ansi-language: EN-IN;mso-fareast-language:EN-IN;mso-bidi-language:AR-SA" lang="EN-IN">Synthesis and reactions of some new 5-aryl-3-oxo-7 -(4'-aryl-2' ,5 '-dioxo-1', 2' ,3 ', 4'-tetrahydrofluoren-3'-yl)-5<i style="mso-bidi-font-style:normal">H</i>, 8<i>H-</i><span style="mso-bidi-font-style: italic">2,3<i>- </i>dihydrothiazolo[5<i>,</i><span style="mso-bidi-font-style: italic">4-<i>b</i>]pyrimidines of expected biological activity</span></span></span>

Abstract

739-7422-Arylidene-indane-1,3-dione 1 on treatment with acetyl acetone in gl. acetic acid gives 3-acetyl-4-aryl-2,5-dioxo-1,2,3,4- tetrahydrofluorenes 2a-d which on reaction with benzaldehyde yield 4-aryl-3-cinnamoyl-2, 5-dioxo-1, 2, 3, 4-tetrahydrofluorenes 3a-d. Compounds 3a-d when reacted with thiourea in gl. CH3COOH/Ac2O in the presence of anhyd. sodium acetate afford 4,5-diaryl-6-(4'-aryl-2', 5' -dioxo-1', 2', 3', 4'-tetrahydrofluoren- 3'-yl)-1, 2, 3, 4-tetrahydropyrimidine-2-thiones <b style="mso-bidi-font-weight: normal">4a-d which on treatment with chloroacetic acid furnish 5-aryl-3-oxo-7-(4'-aryl- 2', 5' -dioxo-1',2',3',4' -tetrahydrofluoren-3'-yl)-5H, 8H-2,3-dihydrothi azolo[5,4-b]pyrimidines 5a-d. Compounds <b style="mso-bidi-font-weight: normal">5a-d on condensation with benzaldehyde yield 2-arylmethylene-3-oxo-Sphenyl-7-(4' -aryl-2', 5' -dioxo-1',  2', 3', 4'-tetrahydrotluoren-3'yl)-5H, 8<i style="mso-bidi-font-style: normal">H-2,3-dihydrothiazolo[5,4- b ]pyrimidines 6a-d.</span