Synthesis of novel antibacterial cephalosporin derivatives using microwaves

Abstract

993-997<span style="font-size:16.0pt;mso-bidi-font-size:9.0pt; font-family:" times="" new="" roman";mso-fareast-font-family:"times="" roman";="" mso-ansi-language:en-us;mso-fareast-language:en-us;mso-bidi-language:ar-sa"="">Eight new cephalosporin derivatives have been prepared by the reaction of 5-substituted-2-mercapto-1,3,4- thiadiazoles with cefotaxime acid and cefalothin acid respectively in the presence of boron trifluoride diethyl etherate in acetic acid using microwave irradiation as compared to the conventional method and these derivatives are evaluated for their antibacterial activity.</span